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Antimicrob Agents Chemother ; 57(9): 4584-6, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23817381

ABSTRACT

A carbapenem-resistant Acinetobacter baumannii strain was isolated from the peritoneal fluid of a patient with complicated intra-abdominal infection and evaluated at the Multidrug-resistant Organism Repository and Surveillance Network by whole-genome sequencing and real-time PCR. The isolate was sequence type 25 and susceptible to colistin and minocycline, with low MICs of tigecycline. blaNDM-1 was located on a plasmid with >99% homology to pNDM-BJ02. The isolate carried numerous other antibiotic resistance genes, including the 16S methylase gene, armA.


Subject(s)
Acinetobacter Infections/microbiology , Acinetobacter baumannii/isolation & purification , Peritonitis/microbiology , Plasmids , beta-Lactamases/genetics , Acinetobacter Infections/diagnosis , Acinetobacter Infections/drug therapy , Acinetobacter baumannii/drug effects , Acinetobacter baumannii/enzymology , Acinetobacter baumannii/genetics , Aged , Anti-Bacterial Agents/pharmacology , Colistin/pharmacology , Drug Resistance, Multiple, Bacterial , High-Throughput Nucleotide Sequencing , Honduras , Humans , Male , Methyltransferases/genetics , Methyltransferases/metabolism , Minocycline/analogs & derivatives , Minocycline/pharmacology , Peritonitis/diagnosis , Peritonitis/drug therapy , Tigecycline , beta-Lactamases/metabolism
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