[Prevalence of mutations of resistance to HIV-I reverse transcriptase inhibitors among HIV-infected patients in the Southern Federal District].

To study the regularities in the spread of drug-resistant HIV-1 strains among HIV-infected patients in the Southern Federal District (SFD), the HIV-1 pol gene site encoded for reverse transcriptase was sequenced in the samples taken from 22 HIV-infected SFD patients who received or did not receive antiretroviral therapy (ARVT). Analysis of the primary sequences of the HIV-1 pol gene in SFD patients untreated with antiviral agents revealed the absence of both primary and secondary mutations of resistance to a nucleoside reverse transcriptase inhibitor (NRTI) and a non-nucleoside reverse transcriptase inhibitor (NNRTI). The group of patients receiving antiviral treatment was found to have different drug resistance mutations in the HIV-1 pol gene: K70R, M184V, K219Q, T215Y/F, L74V, etc. Moreover, the patients on ARVT had higher CD4 T lymphocyte levels and higher immunoregulatory index in the presence of significantly lower HIV replication than the untreated patients. The authors make recommendations how to study HIV resistance in patients who are to be treated and are receiving ARVT and advise to monitor the spread of drug-resistant HIV strains in the SFD.

[Use of anti-radical protection enzymes in the treatment of acute experimental pancreatitis]. / Primenenie fermentov antiradikalnoi zashchity v lechenii ostrogo éksperimentalnogo pankreatita.

Effect of the complex of antiradical enzymes (superoxide dismutase and catalase in proportion 1:3) was studied on the experimental mode of acute pancreatitis. After thrice repeated administration of a complex of enzymes, antioxidant capacity of the blood serum normalized, activity of the enzymes of antioxidant protection of an organism and that of glucose-6-phosphate dehydrogenase increased, concentration of extra-erythrocytic hemoglobin decreased, contributing to normalization of morphologic structure of the pancreas in 52% of the animals with hemorrhagic and in 70%--with oedematous form pancreatitis. The results obtained are indicative of possible correction of the changes in inflammatory process in the pancreas.

[Erythrocyte membranes and antioxidant provision in experimental acute pancreatitis]. / Membrany éritrotsitov i antioksidantnaia obespechennost' pri eksperimental'nom ostrom pankreatite.

Experiments were conducted on rats with induced edematous and hemorrhagic forms of acute pancreatitis (AP) to study the parameters characterizing the state of the red cell membranes: hemolytic efficiency, glucose-6-phosphate dehydrogenase activity, extra-erythrocytic hemoglobin concentrations. The values characterizing the bio-antioxidative defense were also studied: superoxide dismutase activity and antioxidative property. The development of experimental AP is attended by injury to the red cell membranes among the causes of which is poor antioxidative provision.