ABSTRACT
Immunohistochemical detection of the LYVE-1 marker in healthy human full-thickness skin (the epidermis and the dermis) was carried out. LYVE-1 expression was found in the endothelium of lymphatic capillaries located in the papillary dermis, in the endothelium of larger lymphatic vessels of the reticular dermis, and in fibroblasts, which indicates their joint participation in hyaluronan metabolism. LYVE-1+ staining detected for the first time in cells of the stratum basale, the stratum spinosum, and the stratum granulosum of healthy human epidermis indicates their participation in hyaluronan metabolism and allows us to consider the spaces between epidermis cells as prelimphatics.
Subject(s)
Epidermis , Hyaluronic Acid , Lymphatic Vessels , Skin , Vesicular Transport Proteins , Humans , Hyaluronic Acid/metabolism , Vesicular Transport Proteins/metabolism , Vesicular Transport Proteins/genetics , Skin/metabolism , Lymphatic Vessels/metabolism , Epidermis/metabolism , Ligands , Fibroblasts/metabolism , Dermis/metabolism , Lymphatic System/metabolism , Adult , Female , Male , ImmunohistochemistryABSTRACT
Skin, muscle and fat biopsy of a patient with Teutschlander syndrome was studied with light microscopy. Atrophy, sclerosis and lymphostasis of all layers of the skin with small inorganic crystals, with foreign body granulomas or without inflammatory reaction in papillary and reticular layers were observed. Fat tissue under the skin was completely replaced by masses of extra-cellular lipids. The same deposits were found in some muscles with necrosis and degradation of myofibrils. Disturbance of lipid metabolism may be a primary mechanism of this pathology.
