ABSTRACT
In 68 patients with imperfectly united fracture of the crural bones who underwent treatment with the use of the Ilizarov's method, the processes of mineralization of the osseous regenerate being formed were studied. The most rapid deposition of the mineral substances was noted in gradual elimination of a deformity. In shortening of an extremity, the rate of mineralization depended on a size of the elongation performed. Increase in content of the osteotropic hormones and cyclic. nucleotides was indicative of the presence of favourable conditions for formation of osseous regenerate in correction of angular deformity by means of the Ilizarov's method.
Subject(s)
Bone Regeneration , Calcification, Physiologic , Fractures, Malunited/physiopathology , Hormones/blood , Tibial Fractures/physiopathology , Bone Density , Fracture Fixation, Internal , Fractures, Malunited/blood , Fractures, Malunited/surgery , Humans , Leg Length Inequality/blood , Leg Length Inequality/physiopathology , Leg Length Inequality/surgery , Nucleotides, Cyclic/blood , Orthopedic Fixation Devices , Tibial Fractures/blood , Tibial Fractures/surgery , Time FactorsABSTRACT
Roentgenoradiological control of a reparative process after diaphysial comminuted shoulder fractures was exercised at all stages of the treatment after G. A. Ilizarov's method. Osteoscanning permitted the assessment of the viability of bone splinters on the first days after trauma and quantitative assessment of the activity of osteogenesis. A study of the optical density of radiograms provided an opportunity for evaluation of mineral content in regenerating bones, their structure only at late stages of treatment when it was rather high.
Subject(s)
Fracture Fixation, Internal/instrumentation , Osteogenesis/physiology , Shoulder Fractures/surgery , Adult , Aged , Diphosphates , Humans , Middle Aged , Radiography , Radionuclide Imaging , Shoulder Fractures/diagnostic imaging , Technetium , Technetium Tc 99m PyrophosphateABSTRACT
Distinct alterations in content of cyclic nucleotides were observed during treatment of 133 patients with fractures of long tubular bones. The following effects were found after initial increase in cAMP content: increase in tissue permeability, aseptic inflammation, inhibition of cell mitosis, acceleration of cell enzymes synthesis, of protein biosynthesis and of the rate of microcirculation in the traumatized region. Elevation of cGMP concentration led to initiation of bone marrow proliferation, to augmented formation of organic matrix and its mineralization. Monitoring of cyclic nucleotides concentration enabled to evaluate the reparative osteogenesis activity.
Subject(s)
Cyclic AMP/metabolism , Cyclic GMP/metabolism , Fractures, Closed/metabolism , Fibula/injuries , Fracture Fixation , Fractures, Closed/therapy , Humans , Tibia/injuries , Wound HealingSubject(s)
Aging/metabolism , Bone and Bones/metabolism , Leg/metabolism , Minerals/metabolism , Adolescent , Adult , Female , Humans , Male , Reference ValuesABSTRACT
Repair osteogenesis is associated with a certain pattern of change in bone tissue metabolism: metabolic processes are first enhanced continuously and, reaching a peak, grow weaker. Radioisotopic evidence demonstrates that osteogenesis is concluded within 7 to 8 weeks where the fractures involve no bone displacement, and 9 to 10 weeks where the bones were displaced by fracture.
