ABSTRACT
Inflammatory bowel diseases (IBD) are chronic recurrent immune-mediated inflammation of the gastrointestinal tract. Now it is not unified system of monitoring patients with IBD in Russia, but there is information from different regions about the prevalence of disease. There are the registers in few big cities. From 2003 the registers of IBO have been done in Novosibirsk. The register data can give us the possibility to estimate the various real-time data of the disease, to analyze the effect of the treatment, to evaluate risk factors for the disease in real clinical practice. Among the patients with ulcerative colitis decreased the number ofpatients with recurrent and continuous increase in the number of patients with distal forms, which is probably due to the more skillful conduct of patients. in general, it decreased the number of patients with Crohns disease with continuously relapsing course option, reflecting, perhaps, improved treatment. Decline in the proportion of persons with the localization process, only in the colon, which is associated with greater availability of diagnostic methods for destruction of the small intestine. The registry was created in April 2012 and includes patients registered up to October 2015.
Subject(s)
Inflammatory Bowel Diseases/diagnosis , Inflammatory Bowel Diseases/therapy , Registries , Adult , Female , Humans , Inflammatory Bowel Diseases/epidemiology , Male , Siberia/epidemiologyABSTRACT
AIM: To determine prevalence of irritable bowel syndrome (IBS) and associated factors in a community-based population of adolescents. MATERIAL AND METHODS: 189 schoolboys and 250 schoolgirls aged 14-17 years from four randomly chosen schools of Novosibirsk participated in the study. RESULTS: The prevalence of IBS defined according to Rome criteria was higher in girls (24 vs 14% in boys, p = 0.01). Colonic pain frequency was similar in both genders (11% in girls vs 9% in boys, p = 0.46), however disturbed defecation occurred significantly more often in girls than in boys (16 vs 7%, p = 0.003). Half of the subjects who reported IBS had also dyspeptic symptoms. Fiber-rich diet and/or laxatives to prevent constipation were used by 2% of boys and 7% of girls (p = 0.012). However, only one third of those having less than 3 stools a week thought it abnormal. IBS is associated with the age over 15-16 years, female gender, abdominal pain in childhood, appendectomy, irregular meals and smoking (in girls). No association was found with other socio-demographic factors and serological markers of some infections and invasions (H. pylori, G. lamblia, O. felineus, hepatitis viruses B and C). Of the persons with diagnosable IBS, 49% have consulted a physician about it, 21% have undergone upper endoscopy. School absenteeism was reported by 62% of the IBS sufferers. CONCLUSION: IBS is common among adolescents (especially girls) with the prevalence rates similar to those described in adults from West Europe and USA. These disorders are associated with significant disability and health care costs.
Subject(s)
Colonic Diseases, Functional/epidemiology , Adolescent , Age Factors , Colonic Diseases, Functional/diagnosis , Colonic Diseases, Functional/etiology , Cross-Sectional Studies , Female , Humans , Male , Risk Factors , Sex Factors , Siberia/epidemiologyABSTRACT
HDL-subfraction was studied in blood serum of drinkers after alcohol intake and control group of men-nondrinkers. Blood serum incubation with fibroblasts culture did not indicate principal differences between drinkers and nondrinkers both with normolipemia and hyperalphacholesterolemia. Increase of HDL2 and decrease of HDL3-subfraction were observed. Incubation of the same species with hepatoma cells culture (Hep G-2) demonstrated significant differences between normolipemia and hyperalphacholesterolemia. The reduction of HDL2 subfraction level and increase of HDL3 have been found in nondrinkers with normolipemia. The raise of HDL2 was demonstrated in hyperalphacholesterolemia (due to HDL2b and HDL2a in drinkers and HDL2a in nondrinkers). Besides, in several samples of normolipidemic blood serum taken after alcohol abuse the changes of HDL-subfractions were identical to those receiving in hyperalphacholesterolemia. It is postulated that one of the mechanisms of the alcoholic hyperalphacholesterolemia development is the decline of the transfer rate of cholesterol ethers to the liver and accumulation of HDL2 particles in total HDL pool.
