ABSTRACT
Background In a suspected case of biliary obstruction with clinical and laboratory data suggesting obstructive jaundice, the major goal is to confirm the presence of obstruction, its nature and cause, location, and extent. Ultrasonography (USG) and magnetic resonance cholangiopancreatography (MRCP) are primarily used to diagnose suspected biliary tract illnesses. The aim of the study is to evaluate and compare the accuracy of MRCP and USG with endoscopic retrograde cholangiopancreatography (ERCP)/surgical/histopathological outcomes for finding the cause and level of obstruction in the case of clinically suspected biliary obstruction. Methods This was a prospective observational study conducted at Kalinga Institute of Medical Sciences and Pradyumna Bal Memorial Hospital, Bhubaneswar, India, from September 2020 to September 2022 on 120 patients. It included patients with clinical suspicion of biliary obstruction who underwent both USG and MRCP. Characteristics of the obstruction were evaluated for both benign and malignant lesions through USG and MRCP. The findings were then correlated with ERCP, histopathology, or surgery to calculate the diagnostic performance of the former two modalities. Results Out of 120 patients, USG was correctly able to predict the cause of obstruction in 40 patients. The sensitivity, specificity, and accuracy of detecting the nature of obstruction by USG were 33.3%, 84%, and 48.9%, respectively. The overall diagnostic accuracy of USG in predicting the site of obstruction was 64.3%. MRCP was correctly able to predict the cause of obstruction in 113 patients. The sensitivity, specificity, and accuracy of detecting the nature of obstruction by MRCP were 94.1%, 91.9%, and 94.8% respectively. The overall diagnostic accuracy of MRCP in predicting the site of obstruction was 98.33%. Out of 120 patients, no cause of biliary obstruction could be found in 71 patients by USG, out of which the correct diagnosis was made in 67 patients through MRCP. Conclusion USG should be used as the initial screening modality of choice for predicting the level and nature of obstruction in patients with a clinical suspicion of obstructive jaundice. MRCP should be the radiological investigation of choice in patients with clinical suspicion of obstructive jaundice. MRCP has the potential to become the new "Gold standard" investigation for diagnosis in patients with biliary obstruction owing to its excellent diagnostic performance, and non-invasiveness.
