ABSTRACT
Primary pancreatic sarcomas are rare malignancies with an incidence of 0.1%. This case report is of a 48-year-old man who presented with this condition. The patient's treatment plan consisted of distal pancreatectomy and splenectomy with intraoperative immunohistochemistry and adjuvant chemotherapy. To correctly identify and treat undifferentiated pleomorphic sarcoma, a stepwise strategy involving cross-sectional imaging and extensive histopathology analysis is necessary.
ABSTRACT
Pancreaticocutaneous fistulas (PCFs) may be refractory to medical therapy or endoscopic retrograde cholangopancreaticography. Four patients underwent endoscopic ultrasound-guided management of refractory PCFs, which were internalized by endoscopic ultrasound-guided transmural puncture of the pancreatic duct (n = 2), fistula tract (n = 1), or both (n = 1), with placement of transmural stents providing internal drainage to the stomach (n = 3) or duodenum (n = 1). Drainage from PCFs ceased in all patients, and all percutaneous drains were removed; internal stents were left in place indefinitely. Endoscopic ultrasound-guided interventions may successfully treat PCFs, allowing removal of percutaneous drains, and are an attractive alternative for patients who might otherwise require pancreatic resection.
ABSTRACT
Disconnected pancreatic duct syndrome is a sequela of necrotizing pancreatitis or pancreatic trauma in which necrosis of a segment of the pancreas leads to lack of continuity between viable secreting pancreatic tissue (eg, body or tail) and the gastrointestinal tract. The endoscopic retrograde cholangiopancreatography showing total cutoff of the pancreatic duct along with an enhancing distal pancreas on contrast-enhanced computed tomography remains the criterion standard for diagnosis. Recently, the evolving literature supports a role for magnetic resonance cholangiopancreaticography, especially with secretin stimulation. A multidisciplinary approach is extremely important in the management of this condition. Conservative measures are usually not helpful, and interventional radiology, endoscopic, or surgical intervention is almost always needed for management of these patients. Recently, endoscopic ultrasonography-guided drainage procedures in conjunction with endoscopic retrograde cholangiopancreatography-assisted pancreatic duct stenting have emerged as a novel technique to manage this condition. The aim of this review was to give a detailed overview about the diagnosis and management of disconnected pancreatic duct syndrome with emphasis on the changing paradigm in endoscopic and surgical management.
Subject(s)
Cholangiopancreatography, Endoscopic Retrograde/instrumentation , Pancreatectomy , Pancreatic Ducts/surgery , Pancreatic Fistula/surgery , Stents , Abdominal Injuries/epidemiology , Cholangiopancreatography, Endoscopic Retrograde/adverse effects , Cholangiopancreatography, Magnetic Resonance , Drainage , Humans , Necrosis , Pancreatectomy/adverse effects , Pancreatic Ducts/injuries , Pancreatic Ducts/pathology , Pancreatic Fistula/diagnosis , Pancreatic Fistula/epidemiology , Pancreatitis, Acute Necrotizing/epidemiology , Postoperative Complications/etiology , Predictive Value of Tests , Prevalence , Risk Factors , Syndrome , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
Significant literature on the management of acute severe acute pancreatitis has emerged in recent years. The new information ranges from data on newer single or multiparameter severity assessment tools and classification systems to therapeutic modalities. However, a few basic issues-the ideal severity assessment modality, volume of intravenous fluids required in the first 48 to 72 h, and the role of prophylactic antibiotics-are still not clear and are subject to controversy. The International Working Group has devised the Revised Atlanta Classification, which will be published soon. This new classification is eagerly awaited worldwide, and hopefully clarifies many of the problems of the original Atlanta Classification. In this article, we discuss the developments that have arisen in the past 2 to 3 years concerning the classification, prognostication, and early management of severe acute pancreatitis.
Subject(s)
Pancreatitis/therapy , Acute Disease , Antibiotic Prophylaxis , Cholangiopancreatography, Endoscopic Retrograde , Enteral Nutrition , Fluid Therapy , Humans , Pancreatitis/classification , Pancreatitis/complications , Pancreatitis/diagnosis , Pancreatitis, Acute Necrotizing/prevention & control , Pancreatitis, Acute Necrotizing/therapy , Parenteral Nutrition , Prognosis , Severity of Illness Index , Sphincterotomy, EndoscopicABSTRACT
Screening for colorectal cancer has become the standard of care and is currently recommended by most major health organizations, including the American Cancer Society. Randomized controlled trials using fecal occult blood testing as the screening strategy have shown a reduction in mortality due to colorectal cancer. However, colorectal cancer differs from other cancers in that a variety of screening tests have been approved and recommended by experts. The advantages and disadvantages of different screening tests have been the subject of intense debate. Colonoscopy has theoretical advantages over other screening tests, including direct visualization of the entire colon and, more importantly, removal of precancerous adenomatous lesions. This review discusses the advantages and disadvantages of colonoscopy as a screening test for colorectal cancer with regard to efficacy, cost-effectiveness, and patient compliance.
