ABSTRACT
Flucloxacillin is a penicillin antibiotic used as first-line treatment for soft tissue infections caused by Staphylococcus aureus It is used frequently in the elderly and is an established cause of cholestatic liver injury. Risk factors for cholestasis include prolonged duration of treatment, female sex and older age. Elderly patients are also more likely to suffer from comorbidities and polypharmacy, which increases the incidence of drug-induced liver injury and hospitalisation, which in turn can lead to irreversible deterioration in functional baseline. Our case report aims to raise awareness of flucloxacillin-induced liver injury in elderly patients and to encourage the use of alternative treatments and/or limited duration. We advocate for further research into individualised treatments and new diagnostic techniques in patients with painless jaundice based on their genotype.
Subject(s)
Chemical and Drug Induced Liver Injury, Chronic , Chemical and Drug Induced Liver Injury , Cholestasis , Aged , Chemical and Drug Induced Liver Injury/diagnosis , Chemical and Drug Induced Liver Injury/etiology , Female , Floxacillin/adverse effects , Humans , LiverABSTRACT
The COVID-19 pandemic has seen the rapid introduction of innovative schemes to maximise the medical workforce and utilise untapped capacity within the NHS. One such innovation was the recruitment of final year medical students as medical support workers (MSWs) immediately following their final examinations and 4 months before they would have traditionally been employed in their foundation year 1 (FY1) roles. In this article we will describe how a unique programme, with a focus on welfare and pastoral support, was developed and implemented at a hospital in North London and illustrate why the overwhelmingly positive feedback from both the participants and their supervisors has had implications for how medical student training has been shaped for the September 2020 intake at this hospital.
