ABSTRACT
We have studied motor performance in a man with Parkinson's disease (PD) in whom thermolytic lesions of the left subthalamic and left globus pallidus nuclei interrupted the basal ganglia (BG)-thalamo-cortical motor circuit in the left hemisphere. This allowed us to study remaining motor capabilities in the absence of aberrant BG activity typical of PD. Movements of the left arm were slow and parkinsonian whereas movement speed and simple reaction times (RT) of the right (operated) arm were within the normal range with no obvious deficits in a range of daily life activities. Two main abnormalities were found with the right hand. (a) Implicit sequence learning in a probabilistic serial reaction time task was absent. (b) In a go/no-go task when the percent of no-go trials increased, the RT superiority with the right hand was lost. These deficits are best explained by a failure of the cortex, deprived of BG input, to facilitate responses in a probabilistic context. Our findings confirm the idea that it is better to stop BG activity than allowing faulty activity to disrupt the motor system but dispute earlier claims that interrupting BG output in PD goes without an apparent deficit. From a practical viewpoint, our observations indicate that the risk of persistent dyskinesias need not be viewed as a contraindication to subthalamotomy in PD patients since they can be eliminated if necessary by a subsequent pallidotomy without producing deficits that impair activities of daily life.
Subject(s)
Basal Ganglia/physiology , Globus Pallidus/surgery , Neurosurgical Procedures , Parkinson Disease/surgery , Subthalamic Nucleus/surgery , Aged , Biomechanical Phenomena , Executive Function/physiology , Fluorodeoxyglucose F18 , Functional Laterality/physiology , Humans , Learning/physiology , Magnetic Resonance Imaging , Male , Motor Cortex/physiology , Parkinson Disease/diagnostic imaging , Parkinson Disease/pathology , Posture , Psychomotor Performance/physiology , Radionuclide Imaging , Radiopharmaceuticals , Reaction Time/physiology , Time Perception/physiology , Transcranial Magnetic StimulationABSTRACT
Practice of a motor task leads to an increase in amplitude of motor-evoked potentials (MEP) in the exercised muscle. This is termed practice-dependent plasticity, and is abolished by the NMDA antagonist dextromethorphan and the GABA(A) agonist lorazepam. Here, we sought to determine whether specific subtypes of GABA(A) circuits are responsible for this effect by comparing the action of the non-selective agonist, lorazepam with that of the selective GABA(A)-alpha(1) receptor agonist, zolpidem. In seven healthy subjects, transcranial magnetic stimulation (TMS) was used to quantify changes in amplitude of MEP after practice of a ballistic motor task. In addition we measured how the same drugs affected MEP amplitudes and the excitability of a number of cortical inhibitory circuits [short-interval intracortical inhibition (SICI), short-interval afferent inhibition (SAI) and long-interval intracortical inhibition]. This allowed us to explore correlations between drugs effects in measures of cortical excitability and practice-dependent plasticity of MEP amplitudes. As previously reported, lorazepam increased SICI and decreased SAI, while zolpidem only decreased SAI. The new findings were that practice-dependent plasticity of MEPs was impaired by lorazepam but not zolpidem, and that this was negatively correlated with lorazepam-induced changes in SICI but not SAI. This suggests that the intracortical circuits involved in SICI (and not neurons expressing GABA(A)-alpha(1) receptor subunits that are implicated in SAI) may be involved in controlling the amount of practice-dependent MEP plasticity.
Subject(s)
Evoked Potentials, Motor , Lorazepam/pharmacology , Motor Cortex/physiology , Neuronal Plasticity , Pyridines/pharmacology , Adult , Analysis of Variance , Cross-Over Studies , Double-Blind Method , Evoked Potentials, Motor/drug effects , Female , GABA Modulators/pharmacology , GABA-A Receptor Agonists , Humans , Male , Motor Activity/drug effects , Motor Cortex/drug effects , Practice, Psychological , Transcranial Magnetic Stimulation , ZolpidemSubject(s)
Cycloserine/pharmacology , Excitatory Amino Acid Antagonists , N-Methylaspartate/physiology , Theta Rhythm/drug effects , Transcranial Magnetic Stimulation , Adult , Cerebral Cortex/physiology , Double-Blind Method , Evoked Potentials, Motor/drug effects , Female , Humans , Male , Receptors, N-Methyl-D-Aspartate/antagonists & inhibitorsABSTRACT
The objective was to assess the efficacy of dural tenting sutures as a prophylactic measure against extradural haemorrhage following craniotomy. A comparison was made of postoperative extradural haemorrhage between a surgeon always using tenting sutures and a surgeon who never uses them. The subjects consisted of 130 adult patients, 44 with postoperative scans, with normal blood coagulation who underwent elective supratentorial craniotomy (September 1998 to December 2000). Outcome measures were haematoma volume and midline shift as measured on CT and reoperation due to extradural haematoma. The group using tenting sutures had larger median extradural haematoma (2.5 vs 2.0 ml) and midline shift (3 vs 0 mm) than the omitting group. These differences were not significant (P = 0.74 and 0.84). Reoperation due to extradural haemorrhage occurred in 3.6% of the group using tenting sutures and in 0% of the group omitting them. Prophylactic dural tenting sutures do not reduce the size of extradural haematomas in this study. A prospective, randomized trial is needed to eliminate surgeon bias.
