ABSTRACT
In this investigation, we explored the correlation between first-trimester biochemical markers and the incidence of preterm birth (PTB), irrespective of the cause, spontaneous preterm birth (sPTB), and preterm premature rupture of membranes (pPROM) within a cohort comprising 1164 patients. It was discovered that diminished levels of Pregnancy-Associated Plasma Protein-A (PAPP-A) between 11 and 13 + 6 weeks of gestation significantly contributed to the risk of preterm deliveries both before 35 and 37 weeks, as well as to pPROM instances. Furthermore, women experiencing sPTB before the 37th week of gestation also exhibited lower concentrations of PAPP-A. Moreover, reduced first-trimester concentrations of free beta-human chorionic gonadotropin (fb-HCG) were identified as a risk factor for deliveries preceding 37 weeks, pPROM, and sPTB before 35 weeks of gestation. Despite these correlations, the area under the curve for these biochemical markers did not surpass 0.7, indicating their limited diagnostic potential. The most significant discriminatory capability was noted for PAPP-A levels, with a threshold of < 0.71 multiples of the median (MoM) predicting PTB before 37 weeks, yielding an odds ratio of 3.11 (95% Confidence Interval [CI] 1.97-4.92). For sPTB, the greatest discriminatory potential was observed for PAPP-A < 0.688, providing an OR of 2.66 (95% CI 1.51-4.66). The cut-off points corresponded to accuracies of 76.05% and 79.1%, respectively. In regression analyses, the combined predictive models exhibited low explanatory power with R2 values of 9.2% for PTB and 7.7% for sPTB below 35 weeks of gestation. In conclusion, while certain biochemical markers demonstrated associations with outcomes of preterm birth, their individual and collective predictive efficacies for foreseeing such events were found to be suboptimal.
Subject(s)
Biomarkers , Chorionic Gonadotropin, beta Subunit, Human , Pregnancy Trimester, First , Pregnancy-Associated Plasma Protein-A , Premature Birth , Humans , Pregnancy , Female , Pregnancy-Associated Plasma Protein-A/metabolism , Pregnancy-Associated Plasma Protein-A/analysis , Pregnancy Trimester, First/blood , Premature Birth/blood , Premature Birth/epidemiology , Biomarkers/blood , Chorionic Gonadotropin, beta Subunit, Human/blood , Adult , Incidence , Fetal Membranes, Premature Rupture/blood , Fetal Membranes, Premature Rupture/epidemiology , Fetal Membranes, Premature Rupture/diagnosis , Risk FactorsABSTRACT
The first part of the study of 70 women with mechanical sterility analyses social and economical conditions and characteristics of menstrual cycles. It was proved that mechanical sterility was most frequent in urban population older than 25 years. Longer period of therapy before pregnancy was typical of rural population. Earlier menarche had essential effect on duration of therapy. No effect of occupation on duration of therapy was proved.
Subject(s)
Infertility, Female/epidemiology , Adult , Female , Humans , Incidence , Menstrual Cycle/physiology , Poland/epidemiology , Rural Health , Socioeconomic FactorsABSTRACT
The results of the sexual steroids RIA examinations during the menstrual cycle at women with mechanical sterility in confrontation with the group of fertile women were shown. Mean concentrations of progesterone and estradiol in serum were statistically significant in sterile women. In the group of women with mechanical sterility there was no estrogen peak and levels of estradiol in ovulation period were significantly lower in confrontation with the control group.
Subject(s)
Estradiol/blood , Infertility, Female/blood , Menstrual Cycle/blood , Progesterone/blood , Female , Humans , RadioimmunoassayABSTRACT
The paper describes a frequency of clinical manifestations of vulvovaginitis at the group of 277 girls. Duration of therapy and frequency of reinfections were analysed. It was proved, that reinfections occurred four time frequently in mixed infections (caused jointly by specific and non-specific factor) and three time frequently in cases caused by many different species of bacteria. Reinfections were found at 25% of the girls, nine time frequently at only local treated cases. Mixed character of infection and variety of cultured bacteria significantly prolonged the duration of therapy.
