Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Ann Card Anaesth ; 16(1): 11-5, 2013.
Article in English | MEDLINE | ID: mdl-23287080

ABSTRACT

AIMS AND OBJECTIVES: We aimed to compare the hemodynamic effects of levosimendan and dobutamine in patients undergoing mitral valve surgery on cardiopulmonary bypass (CPB). MATERIALS AND METHODS: Sixty patients were divided into 2 groups of 30 each. Group-L patients received levosimendan 0.1 µg/kg/min and Group-D patients received dobutamine 5 µg/kg/min while weaning off CPB. Additional inotrope and/or vasoconstrictor were started based on hemodynamic parameters. Hemodynamic data were collected at the end and at 30 minutes after CPB, thereafter at 6, 12, 24, and 36 hours post-CPB. Mean arterial pressure (MAP), central venous pressure (CVP), heart rate (HR), cardiac index (CI), systemic vascular resistance index (SVRI), and lactate levels were measured. RESULTS: Group-L showed increased requirement of inotropes and vasoconstrictors. The SVRI, CVP, and MAP were reduced more in Group-L. The CI was low in Group-L in the initial period when compared to Group-D. Later Group-L patients showed a statistically significant increase in CI even after 12 hrs of discontinuation of levosimendan infusion. The HR was increased more in Group-D. Lactate levels, intensive care unit stay, and duration of ventilation were similar in both groups. CONCLUSIONS: Levosimendan 0.1 µg/kg/min compared to dobutamine 5 µg/kg/min showed more vasodilation and lesser inotropic activity in patients undergoing mitral valve surgery for mitral stenosis. Levosimendan compared to dobutamine showed a statistically significant increase in CI even after 12 hrs of discontinuation. The requirement of another inotrope or vasopressor was frequent in levosimendan group.


Subject(s)
Cardiotonic Agents/pharmacology , Dobutamine/pharmacology , Heart Valve Prosthesis Implantation/methods , Hemodynamics/drug effects , Hydrazones/pharmacology , Mitral Valve Stenosis/surgery , Mitral Valve/surgery , Pyridazines/pharmacology , Adult , Arterial Pressure/drug effects , Cardiac Output/drug effects , Cardiopulmonary Bypass , Central Venous Pressure/drug effects , Double-Blind Method , Female , Heart Arrest, Induced , Heart Rate/drug effects , Humans , Hypothermia, Induced , Lactic Acid/blood , Male , Prospective Studies , Simendan , Treatment Outcome , Vascular Resistance/drug effects
SELECTION OF CITATIONS
SEARCH DETAIL
...