[The influence of modified sequential therapy on lipid metabolism in postmenopausal women]. / Wplyw wlasnej modyfikacji sekwencyjnej estrogenoterapii na przemiany lipidowe u kobiet w okresie pomenopauzalnym.

The study was performed in 50 women aged 49 to 55 years, divided into two groups. Group I received transdermally at a rising dose of 2 to 8 mg, altogether 16 mg during the therapeutic cycle of 20 days. Group II received estriol intravaginally 0.03 mg/day 10 days and 0.06 mg/day for 10 days. During the second part of the therapeutic cycle all women were given progesterone sublingually 25 mg/day for 6 days and 50/day for 6 days. Measurements in serum of total cholesterol, free cholesterol and triglycerides using an enzymic method, of HDL-Ch and LDL-Ch using a precipitation method and of cholesterol esters using thing-layer chromatography were performed before and after 3 months of therapy. It was found that the use of estradiol leads to a significant decrease in the level of triglycerides, total and free cholesterol, LDL-Ch, with a rise in HDL-Ch. The use of estriol leads to a decrease in LDL-Ch only. No changes in the composition of cholesterol esters were found in both groups, with the exception of an insignificant rise in the percentage of cholesterol oleate.

[Effect of immunotherapy on the level of immunoglobulin in serum of women with pruritus of the vulva]. / Wplyw immunoterapii na poziom immunoglobulin w surowicy u kobiet ze swiadem sromu.

This study was performed in 52 women in their early postmenopausal period, divided into two equal groups. The control group included women with menopausal symptoms only, women in the study group demonstrated also pruritus. All women were on estrogen replacement therapy, additionally a bacterial auto-vaccine was administered in the study group. The level of IgG, IgA, IgM was determined by radioimmunodiffusion, IgE with an immunoenzymatic method. It was found that women with pruritus of the vulva had lower levels of IgG and IgM and higher levels of IgA and IgE, as compared with the control group. The auto-vaccine caused a significant (p < 0.05) increase of IgG and IgM and significant (p < 0.05) decrease of IgA and IgE, as compared with initial values.