ABSTRACT
It was investigated the features of microcirculation and mechanisms it's conditioned, under acute administration of sodium nitrite in 5 mg of dry substance per 100 g of body weight. It was shown that acute administration of sodium nitrite leads to the development of methemoglobinemia, arterial and venous hypoxemia, and severe tissue hypoxia. Increase in the diffusion path O2 at methemoglobinemia is caused due to significant hyperhydratation of lung air-blood barrier and its individual layers, and is accompanied by a decrease in both components of the diffusion capacity of the lungs for oxygen: its membrane and blood components. It was revealed that the administration of sodium nitrite has a double effect, leading to inactivation of hemoglobin, as well as to microcirculatory disturbances associated primarily with changes in the regulation of vascular tone. In this initial perfusion per unit volume of tissue per time unit intrinsic for the organism defines a set of mechanisms which are responsible for changes in tissue blood flow under methemoglobinemia.
Subject(s)
Blood Vessels/metabolism , Blood-Air Barrier/metabolism , Hypoxia/blood , Lung/blood supply , Methemoglobinemia/blood , Oxygen/metabolism , Animals , Blood Vessels/drug effects , Blood Vessels/physiopathology , Blood-Air Barrier/drug effects , Diffusion , Hypoxia/chemically induced , Hypoxia/physiopathology , Lung/drug effects , Lung/metabolism , Male , Methemoglobinemia/chemically induced , Methemoglobinemia/physiopathology , Microcirculation/drug effects , Rats , Sodium Nitrite/toxicity , Water/metabolismABSTRACT
It is stated that prophylactic administration of ional (dibunol) and taurine to rats exerts an antihypoxic effect in case of acute hemic hypoxia. It is expressed in a decrease of methemoglobin level in blood, increase of pO2, in the skeletal muscles, normalization of the structure of hematoparenchymatous barriers, prevention or decrease in a fall of the rate of oxygen consumption by tissues.
