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1.
AIDS ; 17 Suppl 3: S95-101, 2003 Jul.
Article in English | MEDLINE | ID: mdl-14565615

ABSTRACT

OBJECTIVES: Description and analysis of the Senegalese Antiretroviral Drug Access Initiative (ISAARV), the first governmental highly active antiretroviral therapy (HAART) treatment programme in Africa, launched in 1998. METHODS AND RESULTS: ISAARV was initially an experimental project designed to evaluate the feasibility, efficacy and acceptability of HAART in an African context. It was based on four principles: collective definition of the strategy, with involvement of the health professionals who would be called on to execute the programme; matching the objectives to available means (gradual enrollment according to drug availability); monitoring by several research programmes; and ongoing adaptation of treatment and follow-up according to the latest international recommendations. Persons qualifying for antiretroviral (ARV) therapy are selected on the basis of immunological and clinical criteria, regardless of economic and social considerations. A system of subsidies was created to favor access to ARV. Following the ARV price reductions that occurred in November 2000, 100% subsidies were created for the poorest participants. Optimal adherence was ensured by monthly follow-up by pharmacists and support groups held by social workers and patient associations. The chosen supply and distribution system allowed drug dispensing to be strictly controlled. CONCLUSION: The ISAARV programme demonstrates that HAART can be successfully prescribed in Africa. This experience has served as the basis for the creation of a national treatment programme in Senegal planned to treat 7000 patients by 2006.


Subject(s)
Acquired Immunodeficiency Syndrome/drug therapy , Anti-HIV Agents/supply & distribution , Antiretroviral Therapy, Highly Active , Developing Countries , Health Services Accessibility , Adult , Anti-HIV Agents/therapeutic use , Antiretroviral Therapy, Highly Active/economics , Child , Drug Costs/statistics & numerical data , Female , Government Programs/organization & administration , Humans , Male , Nonprescription Drugs/supply & distribution , Patient Selection , Pilot Projects , Senegal
2.
AIDS ; 17 Suppl 3: S103-8, 2003 Jul.
Article in English | MEDLINE | ID: mdl-14565616

ABSTRACT

BACKGROUND: Access to programmes providing highly active antiretroviral therapy (HAART) is recent in Africa. In Senegal, a national initiative was launched in 1998. The capacity of African patients to adhere to complex antiretroviral treatments (ARV) is largely unknown. METHODS: We assessed adherence and identified the main reasons for treatment interruption in a prospective observational cohort of patients participating in an ARV access programme in Dakar, Senegal. Adherence was estimated each month on the basis of the patients' stated consumption and on the proportion of the prescribed dose returned unused to the dispensing pharmacy. A total of 158 patients were studied between November 1999 and October 2001. RESULTS: A cross-section analysis showed that the stated level of adherence was high: on average, over the study period, the patients said they had taken 91% of each monthly dose and that they had taken the full monthly dose during two-thirds of the months studied. Adherence tended to be better among patients who were required to make little or no contribution to the cost of their treatment, through an appropriate pricing structure. Adherence was also better with efavirenz-containing regimens than with indinavir-containing regimens. CONCLUSION: These results show that adherence to HAART can be as high in Africa as that generally observed in industrialized countries, and that the cost and type of drug regimen must be taken into account when designing ARV access programmes for poor communities.


Subject(s)
Anti-HIV Agents/administration & dosage , Antiretroviral Therapy, Highly Active/psychology , Developing Countries , HIV Infections/drug therapy , Patient Compliance/statistics & numerical data , Adult , Antiretroviral Therapy, Highly Active/economics , Cross-Sectional Studies , Drug Costs , Female , Government Programs , HIV Infections/psychology , HIV Infections/virology , Humans , Male , Prospective Studies , Reimbursement Mechanisms , Senegal
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