[Molecularly imprinted sorbent for biological fluids sample preparation in forensic toxicology]. / Primenenie molekulyarno imprintirovannogo sorbenta dlya probopodgotovki biologicheskikh zhidkostei v sudebno-khimicheskom analize.

The objective of this work is to evaluate the possibility of biological fluids sample preparation in forensic toxicology using a molecularly imprinted sorbent based on acrylic acid derivatives. Phenylpiracetam has similar physicochemical properties to those of pyrrolidinophenone derivatives and reproduces their behavior during solid-phase extraction. The phenylpiracetam recovery from blood and urine model samples is 75% for concentration range of 100.0-6000.0 ng/ml. The accuracy of phenylpiracetam extraction does not exceed ±12% for blood samples and ±6% for urine samples. The repeatability is no more than 16% and 13% for blood and urine samples, respectively. A study of the cross-reactivity of the molecularly imprinted sorbent with some drugs showed the selectivity of the sample preparation procedure.

[Forecast of the metrological characteristics of the method of the quantitative determination of verapamil in blood in forensic chemical analysis]. / Prognoz metrologicheskikh kharakteristik metodiki kolichestvennogo opredeleniya verapamila v krovi v sudebno-khimicheskom analize.

The aim of the work is to test theoretical prognosis of metrological characteristics of methods of quantitative determination in forensic chemical analysis on the example of method of determination of verapamil content in blood by thin layer chromatography with computer densitometry. The algorithm of prognostic determination of relative error for methods of quantitative analysis in forensic chemical examination using computer program «ChemMetrEvaluation 1.0¼ is offered. The implementation of the algorithm is based on a detailed analysis of error estimation of measurements at the stages of sample preparation, measuring the value of the analytical signal.

[The use of biochemical characteristics of cadaveric blood in the forensic diagnosis of lethal poisoning]. / Ispol'zovanie nekotorykh sudebno-biokhimicheskikh pokazatelei trupnoi krovi pri diagnostike letal'nykh otravlenii.

The purpose of the work is the development of mathematical models in the forensic diagnosis of poisonings by the main groups of toxicologically important substances, on the basis of biochemical characteristics of blood. The most informative forensic and biochemical indicators of cadaveric blood used to detect lethal poisoning are the urea content, total protein content, and the ratio of urea to creatinine. Mathematical models of poisoning can be used to diagnose poisoning with narcotic drugs, psychotropic substances and substitutes of ethyl alcohol.