Subject(s)
Calcium Channel Blockers/administration & dosage , Myocardial Ischemia/drug therapy , Verapamil/administration & dosage , Aged , Angina Pectoris/drug therapy , Angina Pectoris/physiopathology , Chronic Disease , Drug Evaluation , Hemodynamics/drug effects , Humans , Methods , Middle Aged , Myocardial Ischemia/physiopathology , Physical ExertionABSTRACT
The study was undertaken to examine central hemodynamic and carbohydrate metabolic parameters in patients with coronary heart disease (with or without signs of chronic heart failure, Stages I and IIA). The changes in carbohydrate metabolism in CHD patients were detected earlier than those in central hemodynamics. In patients with Stage I heart failure, who had normal resting hemodynamic parameters, metabolic parameters were indicative of abnormalities in carbohydrate metabolism: there was a reduction in carbohydrate tolerance and red blood cell release of insulin in response to glucose load and an increase in blood immunoreactive insulin, erythrocytic glucose-6-phosphate dehydrogenase activity and greater adrenalin- and insulin-containing erythrocytes. It is suggested that it is advisable to determine the above parameters of carbohydrate metabolism in patients with coronary heart disease.
Subject(s)
Carbohydrates/blood , Cardiac Output, Low/physiopathology , Coronary Disease/physiopathology , Hemodynamics , Cardiac Output, Low/blood , Cardiac Output, Low/complications , Coronary Disease/blood , Coronary Disease/complications , Female , Humans , Male , Middle AgedABSTRACT
A study is presented of the central hemodynamics, renal function and water-salt metabolism in 42 patients with ischemic heart disease and chronic circulatory insufficiency (grades I and II) and revealed a deterioration of these indices in this categories of patients manifested in a retention of sodium, deterioration of central hemodynamics after increase of venous inflow.
Subject(s)
Coronary Circulation/physiology , Coronary Disease/physiopathology , Hemodynamics/physiology , Kidney/physiopathology , Water-Electrolyte Balance/physiology , Adult , Chronic Disease , Coronary Disease/complications , Female , Heart Failure/etiology , Heart Failure/physiopathology , Humans , Male , Middle Aged , VeinsABSTRACT
Indices of hemodynamics, some renal functions and mechanisms of their regulation were studied in 29 patients with ischemic heart disease and chronic circulatory insufficiency (grade IIA) and in 27 healthy persons under load conditions. Indices of central hemodynamics and renal function deteriorated in the patients after increase of preloads while there were no essential changes of the activity of renin-angiotensin-aldosteron activity.
Subject(s)
Coronary Disease/physiopathology , Hemodynamics/physiology , Kidney/physiopathology , Adult , Aged , Chronic Disease , Coronary Disease/complications , Female , Heart Failure/etiology , Heart Failure/physiopathology , Humans , Male , Middle Aged , Posture/physiology , Renin-Angiotensin System/physiologyABSTRACT
The present paper studies lipoprotein of human blood plasma in the norm and pathology. The three informational groups of lipoprotein crystals are isolated, which correspond to certain types of diseases. The question of possible diagnostics of some diseases by means of the lipoprotein crystals type in the polarized light is under discussion.