Subject(s)
Kallikreins/physiology , Kinins/physiology , Stomach/physiology , Animals , Bradykinin/administration & dosage , Bradykinin/pharmacology , Cell Division/drug effects , Diuresis/drug effects , Dogs , Drug Interactions , Gastric Mucosa/metabolism , Gastrointestinal Motility/drug effects , Glucocorticoids/physiology , Kallikreins/pharmacology , Mineralocorticoids/physiology , Prostaglandins/physiology , Renin-Angiotensin System , Vasopressins/administration & dosageABSTRACT
Experiments were carried out in 195 albino rats. It was established that in acute peritonitis the rate of absorption of the colloid dye (tryptan blue) was sharply decreased. Kallikrein somewhat increased the absorption rate, especially at early terms while the inhibitor (kontrikal) was shown to substantially decrease it. The mode of injection (intravenous or intraperitoneal) failed to influence manifestations of the biological effect of the drug. The data obtained show that a disturbed absorption from the abdominal cavity may be corrected in acute peritonitis by injections of kallikrein.
Subject(s)
Abdomen/drug effects , Aprotinin/therapeutic use , Kallikreins/therapeutic use , Peritonitis/drug therapy , Abdomen/metabolism , Absorption , Animals , Drug Evaluation, Preclinical , Female , Male , Peritonitis/metabolism , Rats , Rats, Inbred Strains , Trypan Blue/metabolismSubject(s)
Protease Inhibitors/administration & dosage , Surgical Wound Infection/drug therapy , Wound Healing/drug effects , Administration, Topical , Adolescent , Adult , Aged , Anti-Infective Agents, Local/administration & dosage , Child , Child, Preschool , Female , Humans , Infant , Male , Middle Aged , OintmentsSubject(s)
Aprotinin/therapeutic use , Enzyme Inhibitors/therapeutic use , Protease Inhibitors/therapeutic use , Skin/injuries , Wound Healing/drug effects , Wounds, Penetrating/drug therapy , Animals , In Vitro Techniques , Pancreatic Elastase/antagonists & inhibitors , Rats , Wounds, Penetrating/enzymologySubject(s)
Pancreatitis/metabolism , Trypsin Inhibitors/metabolism , Trypsin/metabolism , Abdomen/metabolism , Acute Disease , Animals , RatsABSTRACT
The protease activity of the wound walls and in the wound washings during the experimental skin and muscular wounds treatment with a Trieline-containing ointment, which is an inhibitor of the elastinase, and with some other proteolytic enzymes has been determined on white rats. It is suggested, that the application of such inhibitors suppresses the catabolism rocesses and stimulates the regenerative ones.
