ABSTRACT
he concentration of erythropoietin (EPO) in serum was studied. The study included 122 people divided into two groups. The main group (group 1) consisted of 102 patients with chronic obstructive pulmonary disease (COPD). The control group (group 2), comparable in age and sex, was 20 surveyed, with no signs of respiratory failure. The concentration of EPO was determined by the method of solid-phase enzyme immunoassay (ELISA) using the test system "Erythropoietin-EIA-BEST" (ZAO Vector-Best, Russia). The concentration of EPO in the serum of the patients of the main group significantly exceeded its content in the control group, the median and interquartile range were respectively 12.0 (7.4 - 16.1) mIU / ml in the main group and 7.5 (5.65-8 , 1) mIU / ml in the control group (p = 0.000454). The degree of increase in EPO correlated with the severity of COPD on the GOLD scale. In a pair comparison of the results obtained, significant differences were established between the control group and the G grade subgroup (p (control and C) = 0.021578), and the control group and subgroup D according to the GOLD classification (p (control and D) = 0,000721). An increase in the content of EPO in the blood is probably due to the reaction of the juxtaglomerular nephron apparatus to the formation of hypoxia due to a violation of the function of external respiration. Thus, the study of the concentration of EPO can be used to assess the severity of COPD, and in interpreting the results of this laboratory test, the possibility of increasing its concentration due to impairment of the function of external respiration should be considered.
Subject(s)
Erythropoietin/blood , Pulmonary Disease, Chronic Obstructive/diagnosis , Respiratory Insufficiency/diagnosis , Case-Control Studies , HumansABSTRACT
Connective tissue dysplasia (CTD) occurs in 70% of the patients with obstructive bronchial pathology. It promotes the development of electrical instability of myocardium and life-threatening arrhythmias. We studied electrocardiographic markers of myocardial instability in patients with chronic obstructive bronchial pathology and CTD markers. Such patients were shown to more frequently have ventricular and supraventricular arrhythmias, decreased circadian heart rate index and enhanced heart rhythm variability. Other findings included high frequency of such predictors of sudden cardiovascular death as prolonged and enhanced dispersion. of QT intervals, T-wave microalternation, late atrial and ventricular potentials. The arrhythmic activity and the occurrence of predictors of sudden cardiovascular death increased in the patients aged above 60 vears with obstructive bronchial Pathology and CTD.
