[Spherical crystallization in pharmaceutical technology]. / A szférikus kristályosítás gyógyszertechnológiai vonatkozásai.

Physical properties of crystals, such as size, crystal size distribution and morphology, may predetermine the usefulness of crystalline materials in many pharmaceutical application. The above properties can be regulated with the crystallization process. The spherical crystals are suitable for direct tablet-making because of their better flowability and compressibility properties. These crystals can be used in the filling of the capsule. In this work, the spherical crystals such as "single crystal", "poly-crystals" and agglomerates with other excipients are collected from the literature and the experimental results of the authors. A close cooperation between chemists and the pharmaceutical technologists can help for doing steps in this field.

[Effect of gelatin solution on parameters of tablets containing well-compressible active principles]. / Zselatin-oldat befolyása jól préselhetö hatóanyagot tartalmazó tabletták paramétereire.

Theobromine tablets have been prepared by wet granulation using gelatin solutions of various concentrations. It has been established that film formed from 2 per cent gelatin solution does not assure sufficient binding force. Lamella forming tendency could be observed on tablets. Furthermore, it has been ascertained that tablets proper in respects of both physical parameters and active principle release can be prepared with 5 per cent gelatin solution. It seems to be unnecessary to use 10 per cent gelatin solution. Behaviour of gelatin solutions at compression of starch and their role in active principle release have been discussed. Attention has been drawn to loss of biological value because of the "aging" of the gelatin film.

[Application of beta-cyclodextrin during direct pressing of tablets]. / Beta-ciklodextrin alkalmazása tabletták közvetlen préselése során.

In case of tablets prepared by direct procedure the compressibility of beta-cyclodextrin has been studied. It has been established that beta-cyclodextrin--because of its very good flowing behaviour--can successfully be applied as ingredient in direct pressing. When hardness of tablets has to be increased 20% Avicel pH 101 (VN) has been recommended. By comparative test of 1:1 mol physical mixture of chloramphenicol-beta-cyclodextrin and the granulated product it has been ascertained that method of preparation of products, behaviour of applied solid binding materials and degree of applied pressing force decisively influence the compressibility of products. Furthermore, it has been found that application of beta-cyclodextrin influences advantageously the dissolution rate of active principle from tablets.