1.
Acta Crystallogr Sect E Struct Rep Online
; 65(Pt 1): o144-5, 2008 Dec 17.
Article
in English
| MEDLINE
| ID: mdl-21581603
ABSTRACT
The title compound, C(26)H(23)N(5)O(8), was prepared and its structure investigated to further develop a working hypothesis for the essential binding pharmacophore for ligands of the System Xc- transporter [Patel et al. (2004 â¶). Neuropharmacology, 46, 273-284]. The hydrazone group displays an E geometry and the isoxazole double bond and C=N group of the hydrazone are in an s-cis relationship. The secondary amino NH group forms an intra-molecular N-Hâ¯O hydrogen bond to a ring nitro group. There is a dihedral angle of 44.27â (5)° between the isoxazole plane and the hydrazone group plane.