Subject(s)
Pacemaker, Artificial/history , Animals , Cardiology/history , Equipment Design , History, 20th Century , Humans , United StatesABSTRACT
The authors determined, by an immunochemical method, the alpha-1-antitrypsin, Gc globulin, prealbumin, albumin, haemopexin, transferrin, haptoglobin, IgA, IgG, ceruloplasmin, alpha-2-macroglobulin contents of 98 follicular fluids, 10 peritoneal fluids and 24 blood sera. Out of these proteins analysed, change in the concentration of alpha-1-antitrypsin showed correlation with the maturity and fertilisation of the oocyte. The alpha-1-antitrypsin content was 1.6 +/- 0.26 g/l in the case of mature oocytes, and 3.1 +/- 1.12 g/l in the case of immature ones. Fertilisation was also concomitant of low alpha-1-antitrypsin levels.
Subject(s)
Blood Proteins/analysis , Oocytes/physiology , Ovarian Follicle/analysis , Adult , Age Factors , Female , Humans , Immunochemistry , Immunodiffusion , Peritoneal Lavage , alpha 1-Antitrypsin/analysisABSTRACT
The changes of 13 serum proteins in 53 ovarian tumour patients were studied by the radial immunodiffusion method from the beginning of treatment, during the course of disease. As to the course of the disease, in 6 of them characteristic and significant changes were observed. These were prealbumin, alpha 1-anti-trypsin, orosomucoid, coeruloplasmin, transferrin and haptoglobin. Although the differences could be evaluated as an average of investigations, the value of the examinations is greatly reduced by the very high scatter of the individual values.
Subject(s)
Blood Proteins/analysis , Ovarian Neoplasms/blood , Uterine Neoplasms/blood , Adult , Aged , Ceruloplasmin/analysis , Female , Haptoglobins/analysis , Humans , Middle Aged , Orosomucoid/analysis , Ovarian Neoplasms/drug therapy , Transferrin/analysis , Uterine Neoplasms/drug therapy , alpha 1-Antitrypsin/analysisABSTRACT
The neopterin level of 164 urine samples of ovarian cancer patients was determined by high pressure liquid chromatography. Parallelly, the serum levels of CA 125, CEA and of lipid bound sialic acid were also determined. A good correlation was found both with CA 125 and with lipid-bound sialic acid. There was a closer correlation with the latter both in the patients showing remission and in the active tumour carriers. In patients with negative tumour markers (TM) in the sera examined, a tumour-free state was confirmed in 87.5% by neopterin determinations. Accordingly, authors recommend neopterin determination in patients who face a critical decision.
Subject(s)
Biomarkers, Tumor/urine , Biopterins/analogs & derivatives , N-Acetylneuraminic Acid , Ovarian Neoplasms/diagnosis , Antigens, Tumor-Associated, Carbohydrate/analysis , Biomarkers, Tumor/blood , Biopterins/urine , Carcinoembryonic Antigen/analysis , Female , Humans , Lipids/blood , Neopterin , Ovarian Neoplasms/urine , Sialic Acids/bloodABSTRACT
By thin-layer chromatography, the serum polyamine levels together with those of CA 125, CEA, lipid-bound sialic acid and urinary neopterine were determined in 56 ovarian cancer patients. A correlation was found in the group of clinically active tumour carriers between the clinical finding and the results of polyamine determination only where other tumour markers were suggestive of complete remission.
Subject(s)
Biomarkers, Tumor/blood , N-Acetylneuraminic Acid , Ovarian Neoplasms/diagnosis , Polyamines/blood , Antigens, Tumor-Associated, Carbohydrate/analysis , Carcinoembryonic Antigen/analysis , Female , Humans , Lipids/blood , Putrescine/blood , Sialic Acids/blood , Spermidine/blood , Spermine/bloodABSTRACT
The significance of CEA, AFP, HCG and SP1 determinations in 85 patients with ovarian cancer were analyzed from the point of view of evaluation of the clinical status of the patients. On the basis of the trials it was stated that a satisfactory correlation between the extension of the tumor and the serum CEA level was observed in 26.6% of the cases. The efficiency of monitoring by systematic CEA tests was found to be 17.3%. The determination of AFP and HCG is useful only in cases of tumors with specific histological structures and in problems of differential diagnostics. The testing of SP1 is of no value in clinical practice.