Clinical form of asthma and vaccine immunity in preschoolers.

INTRODUCTION: Asthma is the most common chronic disease in children. Its exacerbation results from allergic and infectious diseases. AIM: To assess the influence of a clinical form of asthma on preschoolers' vaccine immunity following 3 years after the completion of the mandatory vaccination programme. MATERIAL AND METHODS: The study encompassed 172 preschool children with asthma being newly diagnosed, including 140 patients with mild asthma and 32 with moderate asthma, whose vaccine immunity (level of IgG-specific antibodies) was assessed after the mandatory early vaccines had been administered in the early childhood. Monovalent vaccines (HBV + IPV + Hib) along with a three-component combined vaccine (DTwP) and MMR were given to 86 children while a six-component combined vaccine (DTaP + IPV + Hib + HBV) along with a three-component MMR vaccine were administered to the remaining 86 children. The immunity class for particular vaccinations was assessed according to the manufacturers' instructions. RESULTS: Children suffering from mild asthma had considerably more frequently vaccinations administered on time (p < 0.001) and the type of vaccines (monovalent or highly-combined) administered did not have a significant influence on the clinical form of asthma in the children examined (p = 0.6951). Apart from the vaccines against hepatitis B and rubella where considerably more frequently a high level of antibodies occurred in children with mild asthma, the antibody levels to other vaccines, namely diphtheria, tetanus, pertussis, Hib and mumps, were not associated with the severity of asthma. CONCLUSIONS: Moderate asthma may have a negative impact on remote vaccine immunity to HBV and rubella.

Differences in the quality of life dependent on family status of the elderly living in rural areas - a cross-sectional survey.

INTRODUCTION: A factor that conditions the perception of the quality of life (QoL) is having a social network and relationships within it. The quality of life of seniors is assumed to be at a higher level if they are surrounded by those close to them in comparison to those living alone. The aim of the study was to assess differences in the quality of life of elderly rural residents depending on their family status. MATERIAL AND METHODS: Due to the random and mixed selection of respondents, the study comprised a group of 588 representatives living in rural areas of Eastern Poland. The differentiated criterion of the groups of senior respondents was their family situation: living with a family or living alone. Assessment of the quality of life was conducted by means of the WHOQoL-bref questionnaire. The Mann-Whitney tests and Kruskal-Wallis tests were used to carry out statistical analysis of the data. RESULTS: The respondents who lived with their families differed statistically to a significant extent (p<0.005) from those who lived alone. The former gave a better assessment of the majority of the QoL domains: physical, psychological and social. Obtaining higher mean values for the environmental domain among the respondents living alone (M=14.31) seemed to be an atypical and interesting phenomenon because seniors living with their relatives usually assessed that dimension better than those living alone. CONCLUSIONS: The family situation of seniors affected the level of quality of life. Living with their relatives may be expected to be favourable for seniors because it translates into better performance in physical, psychological and social domains. Loneliness, which frequently accompanies old age, leads to the deterioration of the quality of life.

In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children Before the Administration of the First Booster.

INTRODUCTION: The top priority for active immunoprophylaxis of pertussis is the immunisation of infants as they can sometimes develop severe multiple-organ complications. OBJECTIVES: The aim of the work is the identification of factors negatively affecting vaccine immunity to pertussis in preschool children prior to the administration of the first booster. PATIENTS AND METHODS: The research was conducted on 352 children from 4.5 to 5.9 years of age who were hospitalised in the University Children's Hospital in Lublin (Poland) from 1 January 2012 to 31 December 2015. The children taking part in the study had been administered all the mandatory vaccines from their birth to the age of 2 or 2.5 years old according to the Polish Immunisation Program 2008⁻2009. The immunoenzymatic method ELISA (enzyme-linked immunosorbent assay) was applied to assess vaccine immunity to tetanus, diphtheria, pertussis, Haemophilus influenzae type b (Hib), poliomyelitis (IPV), mumps, rubella and measles. The level of vaccine antibodies to hepatitis type B was determined chemilumiscently. RESULTS: The protective antibody titre was not found in 41 (11.65%) children before the administration of the booster. To verify the collective impact of parameters analysed on antibody titre to pertussis, the Generalized Linear Model (GLZ) was used. Gender, type of vaccine, asthma, Hib and mumps antibody titres have been shown to be predictors of vaccine immunity to pertussis. CONCLUSIONS: Immunomodulation considered on the example of titre of IgG antibody to pertussis can serve as a useful model of the assessment of development of acquired immunity after mandatory vaccinations.