Development and validation of a magneto-hydrodynamic solver for blood flow analysis.

The objective of this study was to develop a numerical solver to calculate the magneto-hydrodynamic (MHD) signal produced by a moving conductive liquid, i.e. blood flow in the great vessels of the heart, in a static magnetic field. We believe that this MHD signal is able to non-invasively characterize cardiac blood flow in order to supplement the present non-invasive techniques for the assessment of heart failure conditions. The MHD signal can be recorded on the electrocardiogram (ECG) while the subject is exposed to a strong static magnetic field. The MHD signal can only be measured indirectly as a combination of the heart's electrical signal and the MHD signal. The MHD signal itself is caused by induced electrical currents in the blood due to the moving of the blood in the magnetic field. To characterize and eventually optimize MHD measurements, we developed a MHD solver based on a finite element code. This code was validated against literature, experimental and analytical data. The validation of the MHD solver shows good agreement with all three reference values. Future studies will include the calculation of the MHD signals for anatomical models. We will vary the orientation of the static magnetic field to determine an optimized location for the measurement of the MHD blood flow signal.

Exploring the use of proper orthogonal decomposition for enhancing blood flow images via computational fluid dynamics.

Obtaining high quality patient-specific flow velocity information is not an easy task. Available clinical data are usually poorly resolved and contain a significant amount of noise. We propose a novel approach to integrate computational fluid dynamics with measurement data to overcome this difficulty. By performing a proper orthogonal decomposition of simulated blood flow patterns for a given vascular location with various anatomical configurations it is possible to obtain a basis model for flow reconstruction. This is used to interpolate imaging data intelligently without having to perform a full flow simulation for each individual patient. This work focuses on assessing the feasibility of such a method.

Modeling intravasation of liquid distension media in surgical simulators.

During therapeutic hysteroscopy and transurethral resection of the prostate, intravasation of the liquid distension media into the vascular system of the patient occurs. We present a model which allows the integration of the intravasation process into surgical simulator systems. A linear network flow model is extended with a correction for non-Newtonian blood behavior in small vessels and an appropriate handling of vessel compliance. We employ a fast lookup scheme in order to allow for real-time simulation. Cutting of tissue is accounted for by adjusting pressure boundary conditions for all cut vessels. We investigate the influence of changing distention fluid pressure settings and of the position of tissue cuts. In addition, we quantify the intravasation occurring with different approaches of fluid control, and we compare the performance of direct and iterative solvers applied to the non-linear system of the compliant model. Our simulation predicts significant intravasation only on the venous side, and just in cases when larger veins are cut. The implemented methods allow the realistic control of bleeding for short-term and of the total resulting intravasation volume for long-term complication scenarios. While the simulation is fast enough to support real-time training, it is also adequate for explaining intravasation effects which were previously observed on a phenomenological level only.

Modelling intravasation of liquid distension media in surgical simulators.

We simulate the intravasation of liquid distention media into the systemic circulation as it occurs during hysteroscopy and transurethral resection of the prostate. A linear network flow model is extended with a correction for non-newtonian blood behaviour in small vessels and an appropriate handling of vessel compliance. We then integrate a fast lookup scheme in order to allow for real-time simulation. Cutting of tissue is accounted for by adjusting pressure boundary conditions for all cut vessels. We investigate the influence of changing distention fluid pressure settings and of the position of tissue cuts. Our simulation predicts significant intravasation only on the venous side, and just in cases when larger veins are cut. The implemented methods allow the realistic control of bleeding for short-term and the total resulting intravasation volume for long-term complication scenarios. While the simulation is fast enough to support real-time training, it is also adequate for explaining intravasation effects which were previously observed on a phenomenological level only.

Spin-dependent electron-proton scattering in the Delta-excitation region.

We report on measurements of the cross section and provide first data on spin correlation parameters A(TT') and A(TL') in inclusive scattering of longitudinally polarized electrons from nuclear-polarized hydrogen. Polarized electrons were injected into an electron storage ring operated at a beam energy of 720 MeV. Polarized hydrogen was produced by an atomic beam source and injected into an open-ended cylindrical cell, located in the electron storage ring. The four-momentum transfer squared ranged from Q2 = 0.2 GeV(2)/c(2) at the elastic scattering peak to Q2 = 0.11 GeV(2)/c(2) at the Delta(1232) resonance. The data provide a stringent test of pion electroproduction models.

Spin-momentum correlations in quasielastic electron scattering from deuterium.

The spin-momentum correlation parameter A(V)(ed) was measured for the 2H-->(e-->,e'p)n reaction for missing momenta up to 350 MeV/c at Q2 = 0.21 (GeV/c)(2) for quasielastic scattering of polarized electrons from vector-polarized deuterium. The data give detailed information about the deuteron spin structure and are in good agreement with the results of microscopic calculations based on realistic nucleon-nucleon potentials and including various spin-dependent reaction mechanism effects. The experiment reveals in a most direct manner the effects of the D state in the deuteron ground-state wave function and shows the importance of isobar configurations for this reaction.