Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Biol Blood Marrow Transplant ; 11(10): 797-804, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16182180

ABSTRACT

We analyzed the incidence, etiology, risk factors, and clinical management of hemorrhagic cystitis (HC) in 102 children who underwent allogeneic stem cell transplantation: 28 from matched siblings, 57 from unrelated donors, and 17 from mismatched relatives. Conditioning regimens consisted of high-dose chemotherapy (n=83) or total body irradiation (n=19). In all children, urine and plasma were prospectively screened for human polyomavirus (HPV; BK virus [BKV] and JC virus [JCV]) or adenovirus (AdV) DNA with a polymerase chain reaction-based assay. Viral DNA was detected in the urine of 56 children (54.9%): BKV in 48 (47%), JCV in 4 (3.9%), and AdV in 4 (3.9%). HC occurred in 26 children (25.5%), and viruria was detected in all of them: BKV in 21 (80.8%), AdV in 4 (14.4%), and JCV in 1 (3.8%). All patients with AdV viruria developed HC. The cumulative incidence of HC in patients with HPV viruria was 0.43. The only significant risk factor for HC in patients with HPV-positive urine was conditioning with high-dose chemotherapy. Twenty-two children were treated with cidofovir, with no significant toxicity. In all treated patients but 1, the clinical symptoms were moderate, and no HC-related death was observed. We conclude that virus-induced HC is a frequent complication after allogeneic hematopoietic cell transplantation. Treatment with cidofovir is feasible, and further studies are warranted to evaluate its activity in HC mediated by BKV or JCV.


Subject(s)
Cystitis/virology , Hematopoietic Stem Cell Transplantation/adverse effects , Viruses/isolation & purification , Adenoviridae/isolation & purification , Adolescent , Adult , Child , Child, Preschool , Cidofovir , Cystitis/drug therapy , Cystitis/epidemiology , Cystitis/etiology , Cytosine/analogs & derivatives , Cytosine/therapeutic use , DNA, Viral/blood , DNA, Viral/urine , Disease Management , Female , Hematopoietic Stem Cell Transplantation/methods , Hemorrhage , Humans , Incidence , Infant , JC Virus/isolation & purification , Male , Mass Screening , Organophosphonates/therapeutic use , Polyomavirus/isolation & purification , Prospective Studies , Risk Factors , Transplantation Conditioning/adverse effects , Transplantation Conditioning/methods , Transplantation, Homologous , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL
...