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1.
Clin Genet ; 91(4): 623-628, 2017 Apr.
Article in English | MEDLINE | ID: mdl-27701732

ABSTRACT

Tatton-Brown-Rahman syndrome (TBRS) was recently described in 13 isolated cases with de novo mutations in the DNMT3A gene. This autosomal dominant condition is characterized by tall stature, intellectual disability and a distinctive facial appearance. Here, we report six cases of inherited TBRS caused by novel DNMT3A germline mutations. The affected individuals belong to two sib-ships: four from an Old Order Amish family in America and two from a French Canadian family in Canada. All of them presented with characteristic features of TBRS, including dysmorphic facial features, increased height, intellectual disability, and variable additional features. We performed clinical exome sequencing and identified two mutations in the DNMT3A gene, a c.2312G>A (p.Arg771Gln) missense mutation in the Amish family and a c.2296_2297delAA (p.Lys766Glufs*15) small deletion in the French Canadian family. Parental DNA analysis by Sanger sequencing revealed that the Amish mutation was inherited from the healthy mosaic father. This study reflects the first cases with inherited TBRS and expands the phenotypic spectrum of TBRS.


Subject(s)
DNA (Cytosine-5-)-Methyltransferases/genetics , Genetic Predisposition to Disease , Germ-Line Mutation/genetics , Intellectual Disability/genetics , Adolescent , Adult , Canada , Child , DNA Methyltransferase 3A , Exome/genetics , Facies , Female , Heterozygote , Humans , Intellectual Disability/physiopathology , Male , Middle Aged , Pedigree , Sequence Analysis, DNA
2.
Article in English | MEDLINE | ID: mdl-24747518

ABSTRACT

Since 2008 a significant amount of work has focused on the development of methods to analyze contaminated heparin. This work focuses on utilizing heparin's ability to serve as a chiral selector as a means for determining contamination. Specifically, the effect of contamination on the separation of pheniramine and chloroquine enantiomers was explored. Separations were conducted using heparin contaminated with chondroitin sulfate at varying levels. For each pair of enantiomers, electrophoretic mobility and resolution were calculated. For pheniramine enantiomers, an increase in contamination leads to a decrease in the electrophoretic mobility and resolution. A linear relationship between contamination level and electrophoretic mobility of the pheniramine enantiomers was observed for the entire contamination range. A linear relationship was also found between contamination level and resolution of the enantiomers between 0 and 70 percent contamination. For the separation of chloroquine enantiomers, it was found that at low levels of contamination, the resolution of enantiomers was increased due to the secondary interaction between the chloroquine enantiomers and the chondroitin sulfate. Results of this study illustrate the potential of using chiral recognition as a means to determine heparin contamination as well as the improvement of the chiral resolution of chloroquine with the additional of low levels of chondroitin sulfate A.


Subject(s)
Chloroquine/chemistry , Drug Contamination , Electrophoresis, Capillary/methods , Heparin/chemistry , Pheniramine/chemistry , Isomerism
3.
Genes Brain Behav ; 9(6): 668-72, 2010 Aug.
Article in English | MEDLINE | ID: mdl-20561060

ABSTRACT

The chromosome 1p36 region was previously indicated as a locus for susceptibility to recurrent major depressive disorder based on a linkage study in a sample of 497 sib pairs. We investigated the gamma-aminobutyric acid A (GABA(A)) delta receptor subunit gene, GABRD, as a susceptibility gene to childhood-onset mood disorders (COMD) because of substantial evidence implicating GABAergic dysfunction in mood disorders and the position of this gene near the 1p36 linkage region. Using a sample consisting of 645 Hungarian families with a child/adolescent proband diagnosed with a mood disorder with the onset of the first episode before age 15, we found some evidence for the association of two polymorphisms located within the gene, rs2376805 and rs2376803, as well as significant evidence for biased transmission of the haplotypes of these two markers (global chi(2) test for haplotypes = 12.746, 3 df, P = 0.0052). Furthermore, significant evidence of association was only observed in male subjects (n = 438) when the results were analyzed by sex (chi(2) = 9.000 1 df, P = 0.003 for rs2376805). This was in contrast with the previous linkage findings, as LOD scores exceeding 3 were only in female-female pairs in that study. These findings point to the GABRD gene as a susceptibility gene for COMD; however, this gene may not explain the previous linkage finding.


Subject(s)
Linkage Disequilibrium/genetics , Mood Disorders/genetics , Receptors, GABA-A/genetics , Adolescent , Age of Onset , Female , Genotype , Haplotypes/genetics , Humans , Hungary/epidemiology , Male , Mood Disorders/epidemiology , Nuclear Family , Polymorphism, Single Nucleotide , Sex Factors , gamma-Aminobutyric Acid/metabolism
4.
Acta Physiol Hung ; 96(4): 385-405, 2009 Dec.
Article in English | MEDLINE | ID: mdl-19942547

ABSTRACT

In the first part of this series of papers (Székely and Pataki, 102) the pathogenesis of asthma was approached as a pathological antigen-antibody complex induced vago-vagal axon reflex. In the next part (103) the contribution of individual hormonal predisposition, the environmental and the most frequent allergizing factors have been reviewed. In the first section of this last (third) part of the review the genetic factors contributing to the asthma are surveyed. In this field a great progress has been made during the last decade, a lot of genes have been pinpointed which contribute to the heredity of the disease. In the second section of this last paper on the etiology of asthma an attempt is made to summarize the previously reviewed data and some new ones. Actually a new hypothesis is proposed that beyond the multitude of genetic, environmental and hormonal factors the underlying biochemical mechanism is simple: the disequilibrium of two functionally opposing second messenger systems in the airways: the Ca i ++ liberating PLC-PKC cascade and the Ca i ++ level reducing cAMP mediated one with preponderance of the former.


Subject(s)
Asthma/etiology , Environment , Second Messenger Systems , Animals , Asthma/enzymology , Asthma/genetics , Asthma/immunology , Asthma/physiopathology , Bronchoconstriction , Calcium Signaling , Cyclic AMP/metabolism , Genetic Predisposition to Disease , Humans , Inositol 1,4,5-Trisphosphate/metabolism , Pedigree , Protein Kinase C/metabolism , Reflex, Abnormal , Risk Factors , Type C Phospholipases/metabolism
5.
Acta Physiol Hung ; 96(1): 1-17, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19264038

ABSTRACT

The novel data on the pathogenesis of asthma are summarized in this three-part review. Its immunological background is well established but it is more than an immunological disorder. Multiple lines indicate that both peripheral and central neural mechanisms are also involved in the pathogenesis of asthma. In the present first part of the review asthma is described as vago-vagal axon reflex brought about by multiple positive feed-back mechanisms, receptor upregulation, wind-up, phenotypic switch and formation of a pathological conditioned reflex. In the coming second part the main dispositional (mostly hormonal) and external contributing factors are reviewed, while the third part deals with the role of inheritance, i.e., with gene alleles leading to enhanced production of mediators of asthma.


Subject(s)
Asthma/physiopathology , Axons/metabolism , Bronchial Hyperreactivity , Lung/innervation , Receptors, Neurotransmitter/metabolism , Reflex , Vagus Nerve/physiopathology , Animals , Asthma/immunology , Asthma/metabolism , Humans , Nerve Fibers, Unmyelinated/metabolism , Nerve Growth Factors/metabolism , Phenotype , Receptors, Tachykinin/metabolism , Sensory Receptor Cells/metabolism , TRPV Cation Channels/metabolism , Tachykinins/metabolism , Vagus Nerve/metabolism
6.
Spinal Cord ; 40(9): 468-73, 2002 Sep.
Article in English | MEDLINE | ID: mdl-12185608

ABSTRACT

OBJECTIVE: To investigate the pathomechanism of the rare radiogenic lower motor neurone disease (LMND) on the basis of a case history involving a partial functional recovery. PATIENT: A 31-year-old seminoma patient received postoperative para-aortic and para-iliac telecobalt irradiation with a biologically effective dose of 88 Gy(2) (44 Gy in 2 Gy fractions/day, with an estimated alpha/beta of 2 Gy) delivered to the spinal cord following a single cycle of chemotherapy. LMND developed 4 months after the completion of radiotherapy. The patient exhibited flaccid paraparesis of the lower extremities (without sensory or vegetative signs), followed by a worsening after further chemotherapy, due to pulmonary metastatization. A gradual spontaneous functional improvement commenced and led several years later to a stabilized state involving moderately severe symptoms. METHODS: In the 15th year of the clinical course, magnetic resonance imaging (MRI) and positron emission tomography (PET) with [(18)F]fluorodeoxyglucose (FDG) and [(11)C] methionine were conducted. Four lines of experiments (clonogenic assay using fibroblasts isolated from a skin biopsy sample of the patient, comet assay, micronucleus assay, and the testing of chromosome aberrations after in vitro irradiation of peripheral blood samples) were performed in a search for an increased individual radiosensitivity. RESULTS: MRI investigations failed to reveal any pathological change. PET demonstrated an increased FDG accumulation, but a negligible [(11)C] methionine uptake in the irradiated spinal cord segments. The radiobiological investigations did not indicate any sign of an increased individual radiosensitivity. CONCLUSIONS: We suggest that the observed partial functional recovery and stabilization of the symptoms of radiogenic LMND may be explained by the higher than normal density of sodium channels expressed along the demyelinated axons of the restored conduction. The increased energy demands of this type of conduction are proved by a higher metabolic rate (increased FDG uptake) of the irradiated spinal cord segments without a substantial regenerative process (lack of detectable protein synthesis).


Subject(s)
Cobalt Radioisotopes/adverse effects , Motor Neuron Disease/etiology , Motor Neuron Disease/physiopathology , Radioisotope Teletherapy/adverse effects , Tomography, Emission-Computed , Adult , Fluorodeoxyglucose F18 , Humans , Magnetic Resonance Imaging , Male , Motor Neuron Disease/diagnostic imaging , Motor Neuron Disease/metabolism , Radiopharmaceuticals , Recovery of Function , Seminoma/therapy , Sodium Channels/metabolism , Testicular Neoplasms/therapy , Tomography, Emission-Computed/methods
7.
Pharmazie ; 56 Suppl 1: S22-30, 2001 Oct.
Article in English | MEDLINE | ID: mdl-11686087

ABSTRACT

The contribution of the researchers of IDR to some early discoveries on endorphins is recounted. Exact determination of the amino acid sequence of beta-lipotropin, discovery of the analgesic action of beta-endorphin in rats, demonstration of the partial cross-tolerance between morphine and beta-endorphin, description of the elevation of the pain threshold upon inhibition of the enzymatic breakdown of endogenous opioids by bacitracin, demonstration of inhibition of opiate tolerance and dependence by alpha-MSH and Met-enkephalin, development of the second strongest enkephalin analogue, D-Met2,Pro5-enkephalinamide, recognition of some factors conferring analgesic activity to synthetic enkephalin analogues, etc. prove that IDR has played an active role in the early history of endorphin research.


Subject(s)
Endorphins/history , Pharmacology/history , Animals , Endorphins/chemistry , Endorphins/pharmacology , History, 20th Century , Humans , Hungary
8.
J Urol ; 166(1): 222-4, 2001 Jul.
Article in English | MEDLINE | ID: mdl-11435873

ABSTRACT

PURPOSE: To our knowledge despite numerous studies the biological effect of extracorporeal shock wave lithotripsy (ESWL, Dornier Medical Systems, Inc., Marietta, Georgia) on the function of the immature kidney has not yet been evaluated. We determined the short-term effect of ESWL on renal function in children. MATERIALS AND METHODS: In a 5-year period 65 children were treated for 77 kidney stones by ESWL and followed regularly at our department. In 16 children the short-term effect of shock wave energy was studied by measuring blood parameters (sodium, potassium, urea, creatinine and C-reactive protein), urinary electrolytes (sodium, potassium and creatinine), urinary enzyme activity (aspartate transaminase, alanine transferase, alkaline phosphatase and lactate dehydrogenase) and the excretion of beta 2-microglobulin. Samples were obtained immediately before and 2 hours after ESWL, and on days 1, 2, 8, 15, 30 and 90 after treatment. RESULTS: Morphological changes in the kidneys were not detected by ultrasound during followup. No significant changes were noted in overall renal function, serum parameters or urine electrolytes. A significant elevation in the excretion of aspartate transaminase, alkaline phosphatase, lactate dehydrogenase and beta 2-microglobulin was observed, indicating proximal tubular dysfunction and cell destruction. Enzyme levels returned to baseline within 15 days. CONCLUSIONS: Our results demonstrate that shock wave energy induces transient functional damage of tubular function in children. Minimizing the kV. and number of shocks may decrease the deleterious effect. When considering functional regeneration time, the minimal interval between 2 shock wave treatments should be at least 15 days. The long-term effect needs further investigation.


Subject(s)
Kidney Calculi/therapy , Kidney Function Tests , Lithotripsy/methods , Adolescent , Child , Female , Follow-Up Studies , Humans , Kidney Calculi/diagnosis , Lithotripsy/adverse effects , Male , Recovery of Function , Sensitivity and Specificity , Time Factors , Treatment Outcome
9.
Acta Pharm Hung ; 71(1): 25-39, 2001.
Article in Hungarian | MEDLINE | ID: mdl-11769094

ABSTRACT

The contribution of the research workers of the Institute for Drug Research to some early discoveries in the field of endorphins is reviewed. The author takes pride in the fact the analgesic action of beta-endorphin was described in his laboratory concurrently with an American and a British group, respectively. The other main findings of his laboratory include demonstration of the cross-tolerance between beta-endorphin and morphine, description of the elevation of the pain threshold upon inhibition of the breakdown endogenous opioids by intracerebroventricular administration of bacitracin, attenuation of morphine tolerance by alpha-MSH and Met-enkephalin, pharmacological development and clinical examination of a highly potent enkephalin analogue, (D-Met2,Pro5)-enkephalinamide, coded as GYKI 14,238.


Subject(s)
Analgesics , beta-Endorphin/pharmacology , Animals , Drug Tolerance , Humans , Morphine/pharmacology , Research/trends
10.
Brain Res Bull ; 52(6): 511-7, 2000 Aug.
Article in English | MEDLINE | ID: mdl-10974490

ABSTRACT

The involvement of alpha-amino-3-hydroxy-5-methylizoxazole-4-propionic acid (AMPA) receptors in induction of long-term potentiation (LTP) was examined in rat hippocampal slice preparation. Using conventional extracellular recording, excitatory postsynaptic potentials (EPSPs) and population action potentials (PSs), evoked by low-frequency stimulation of the Schaffer collateral-commissural fibres, were recorded in the CA1 region. The effects of a competitive AMPA receptor antagonist, 6-nitro-7-sulfamoylbenzo(f)quinoxaline-2, 3-dione (NBQX), and that of a non-competitive blocker, 1-(4-aminophenyl)-4-methyl-7,8-methylendioxy-5H-2,3-benzodiazepine (GYKI 52466) have been examined. 0.25-0.5 microM of NBQX and 20-40 microM of GYKI 52466 did not suppress the induction of LTP. LTP was attenuated only at the highest concentrations tested (1 microM NBQX or 80 microM GYKI 52466). These in vitro concentrations, however, exceed the brain levels needed for in vivo anticonvulsant action. Furthermore, even at the highest concentrations both compounds suppressed only the expression but not the induction of LTP. Namely after their washout LTP reappeared. Thus, at pharmacologically relevant concentrations these AMPA receptor antagonists apparently do not suppress LTP, a cellular mechanism underlying memory formation. These experiments suggest that in clinical practice AMPA receptor blockade may have some advantage over N-methyl-D-aspartate receptor antagonism, which is accompanied by severe memory impairment.


Subject(s)
Anti-Anxiety Agents/pharmacology , Benzodiazepines , Excitatory Amino Acid Antagonists/pharmacology , Hippocampus/drug effects , Long-Term Potentiation/drug effects , Neurons/drug effects , Quinoxalines/pharmacology , Receptors, AMPA/drug effects , Animals , Dose-Response Relationship, Drug , Epilepsy/drug therapy , Epilepsy/physiopathology , Excitatory Postsynaptic Potentials/drug effects , Excitatory Postsynaptic Potentials/physiology , Hippocampus/cytology , Hippocampus/metabolism , Long-Term Potentiation/physiology , Male , Memory/drug effects , Memory/physiology , Neurodegenerative Diseases/drug therapy , Neurodegenerative Diseases/physiopathology , Neurons/cytology , Neurons/metabolism , Organ Culture Techniques , Rats , Rats, Sprague-Dawley , Receptors, AMPA/antagonists & inhibitors , Receptors, AMPA/metabolism
11.
Oncology ; 59(2): 118-21, 2000 Aug.
Article in English | MEDLINE | ID: mdl-10971169

ABSTRACT

690 patients were treated for testicular tumour in the course of 18 years. The histology of 7 cases showed Leydig cell tumour. In 4 of the 7 cases, a metastatic process leading to death was observed. At the time of diagnosis, 5 patients were found to have low stage, whereas 2 of the patients had advanced lymphatic involvement. The hematogenous and lymphatic metastases proved to be resistant to chemotherapy. Contrary to the major part of the literature, retroperitoneal lymphadenectomy should be performed with this histological type for the exact pathological staging immediately following orchiectomy.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols , Leydig Cell Tumor , Testicular Neoplasms , Adult , Aged , Bleomycin/therapeutic use , Cisplatin/therapeutic use , Humans , Leydig Cell Tumor/drug therapy , Leydig Cell Tumor/secondary , Leydig Cell Tumor/surgery , Lymph Node Excision , Lymphatic Metastasis , Male , Middle Aged , Testicular Neoplasms/drug therapy , Testicular Neoplasms/pathology , Testicular Neoplasms/surgery , Vinblastine/therapeutic use
12.
Eur J Pharmacol ; 397(1): 43-7, 2000 May 26.
Article in English | MEDLINE | ID: mdl-10844097

ABSTRACT

The effects of various (S)-alpha-amino-3-hydroxy-5-methyl-4-izoxazole-propionate (AMPA) receptor modulators on AMPA-induced whole-cell currents were compared in isolated rat cerebellar Purkinje cells. The positive modulators, aniracetam, cyclothiazide, 1-(1, 3-benzodioxol-5-ylcarbonyl)-piperidine (1-BCP), and 1-(quinoxaline-6-ylcarbonyl)-piperidine (BDP-12), dose-dependently potentiated the steady-state component of AMPA currents. The negative modulator, (-)1-(4-aminophenyl)-4-methyl-7, 8-methylenedioxy-4,5-dihydro-3-methylcarbamoyl-2,3-benzodiazepine (GYKI 53784), dose-dependently suppressed AMPA responses. Its concentration-response curve was shifted to the right in a parallel fashion by all positive modulators, indicating a competitive type of interaction. However, the relative potencies of the positive modulators were different with regard to the enhancement of AMPA responses and the reversal of GYKI 53784-induced inhibition, respectively. It is supposed that positive modulators act at multiple allosteric sites and that they interact with GYKI 53784 at only one of these sites.


Subject(s)
Benzodiazepines/pharmacology , Excitatory Amino Acid Antagonists/pharmacology , Membrane Potentials/drug effects , Purkinje Cells/drug effects , Receptors, AMPA/drug effects , Animals , Benzothiadiazines/pharmacology , Cells, Cultured , Cerebellum/cytology , Cerebellum/drug effects , Cerebellum/physiology , Dioxoles/pharmacology , Dose-Response Relationship, Drug , Drug Synergism , Piperidines/pharmacology , Purkinje Cells/cytology , Purkinje Cells/physiology , Pyrrolidinones/pharmacology , Rats , Receptors, AMPA/physiology , alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology
14.
Orv Hetil ; 140(39): 2177-9, 1999 Sep 26.
Article in Hungarian | MEDLINE | ID: mdl-10533382

ABSTRACT

A 67 year old male patient with macroscopic hematuria was treated by percutaneous intraarterial embolization with Gianturco-coil (Cook). The patient had a percutaneous stone removal from the left kidney two weeks before the bleeding. The emergency angiography showed an arteriovenous shunt in the left kidney. A superselective embolization was performed. There was no bleeding on the control angiography. The embolization was performed without complication.


Subject(s)
Arteriovenous Fistula/etiology , Kidney Calculi/surgery , Aged , Arteriovenous Fistula/diagnosis , Arteriovenous Fistula/surgery , Arteriovenous Shunt, Surgical , Embolization, Therapeutic , Hematuria/diagnostic imaging , Hematuria/etiology , Humans , Male , Postoperative Complications , Urography
17.
Life Sci ; 64(2): 145-52, 1999.
Article in English | MEDLINE | ID: mdl-10069492

ABSTRACT

The dipeptidyl aminopeptidase IV (DP IV) inhibitor Diprotin A produces a full, dose-dependent, short-lasting and naloxone-reversible analgesia in the rat tail-flick test when given intracerebroventricularly, with an ED50 of 295 nmol/rat but it has no direct opioid agonist activity in the longitudinal muscle strip of guinea-pig ileum bioassay. Two of the potential DP IV substrates, morphiceptin and endomorphin 1, identified recently in bovine brain were also analgesic given by similar route. The action of endomorphin 1 was more potent (ED50 = 7.9 nmol/rat) and slightly but significantly more sustained than that of Diprotin A. Diprotin A neither potentiated nor prolonged the effect of a marginally analgesic dose of endomorphin 1. The distinct time course and the lack of potentiation indicate that in the analgesic effect of Diprotin A in rats the protection of a brain Tyr-Pro-peptide other than endomorphin 1 is involved.


Subject(s)
Analgesia , Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/antagonists & inhibitors , Naloxone/pharmacology , Oligopeptides/pharmacology , Analgesics, Opioid/pharmacology , Animals , Dose-Response Relationship, Drug , Drug Synergism , Endorphins/administration & dosage , Endorphins/pharmacology , Guinea Pigs , In Vitro Techniques , Male , Mice , Muscle, Smooth/drug effects , Narcotic Antagonists/pharmacology , Oligopeptides/administration & dosage , Pain Measurement , Rats , Rats, Wistar
18.
Strahlenther Onkol ; 175(12): 606-10, 1999 Dec.
Article in English | MEDLINE | ID: mdl-10633787

ABSTRACT

PURPOSE: To evaluate the total body irradiation methods in the National Institute of Oncology between January 1984 and February 1998. PATIENTS AND METHODS: One hundred and twenty-four patients underwent total body irradiation prior to bone marrow transplantation in the last 15 years. A special cobalt unit has been used, the dose rate was 6 to 8 cGy/min in the midline of the abdomen. The source-midline distance (SMD) was 340 cm and the field size was 80 x 200 cm. The dose calculation was done on the basis of a tissue-phantom ratio curve measured in total body irradiation conditions and effective tissue thickness (ETT). Between 1984 and 1992 the beam direction was horizontal, the patients laid in lateral position. In 11 cases the total dose to the abdominal midline was 10 Gy in 1 fraction. From 1986 the fractionation changed to 4 x 3 Gy in 4 days. Within individual lung shielding the average lung dose was 8.5 Gy. In 44/124 cases the order of conditioning treatment was chemo-radiotherapy. Since 1992 vertical beams were used, and the patients (80/124) laid in prone/supine position. The fractionation remained the same but radio-chemotherapy regime has been used. RESULTS: The irradiation in prone position proved to be safer than lateral because of smaller patient motion and it resulted in a more accurate positioning of lung shielding too. In all cases, the acute side effects (headache, nausea, vomiting) were moderate. Using radio-chemotherapy the acute side effects during the total body irradiation were uncommon and well tolerable. CONCLUSION: Our technique with the large source-midline distance, vertical beam direction and the supine/prone position is stable, convenient and safe to produce homogeneous dose distribution and ensures accurate and reproducible lung shielding.


Subject(s)
Bone Marrow Transplantation , Whole-Body Irradiation/methods , Cobalt Radioisotopes/therapeutic use , Combined Modality Therapy , Humans , Leukemia/radiotherapy , Posture , Radiation Protection/instrumentation , Radiotherapy Dosage , Whole-Body Irradiation/adverse effects , Whole-Body Irradiation/instrumentation
19.
J La State Med Soc ; 150(8): 372-83, 1998 Aug.
Article in English | MEDLINE | ID: mdl-9770948

ABSTRACT

This study of primary care practitioners in Louisiana's Medicaid managed care program, Community Care, focused on the program's implementation and perceived impact. PCPs were interviewed to assess their perceived responsibilities as gatekeepers and how well they believed the system facilitated or impeded their fulfillment of those responsibilities, to examine issues of access and quality, and to determine their knowledge and use of local referral networks. Findings indicate that although they appreciated the financial stability derived from having a larger patient base and understood their roles well, they were concerned with several facets of the program, including perceived limitations imposed on their medical decision making, an added burden of paperwork, and a lack of both downward and upward communication. They also believed the referral network of available providers for medical and social services to be more limited for their Medicaid patients than for their private patients. Policy implications are discussed.


Subject(s)
Managed Care Programs/organization & administration , Medicaid/organization & administration , Primary Health Care/organization & administration , Referral and Consultation , Rural Health Services/organization & administration , Attitude of Health Personnel , Community Networks/organization & administration , Health Care Surveys , Humans , Louisiana , United States
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