ABSTRACT
Authors report on local mitomycin-C (MTM-C) therapy applied subsequent to the treatment by means of Nd-YAG laser in 59 superficial (Ta-T1) bladder neoplasms. Relapse-rate in the neoplasms could be reduced by using MTM-C accompanied by minor side-effects. Seventy-two % of patients have been free from relapse for the mean 44-month follow-up period. Authors also suggest that laser therapy may favourably be completed by local chemoprophylaxis in "high-risk" type superficial bladder neoplasms.
Subject(s)
Carcinoma, Transitional Cell/prevention & control , Carcinoma, Transitional Cell/surgery , Laser Coagulation , Mitomycin/administration & dosage , Urinary Bladder Neoplasms/prevention & control , Urinary Bladder Neoplasms/surgery , Adult , Aged , Chemotherapy, Adjuvant , Female , Humans , Injections, Intralesional , Male , Middle Aged , Neoplasm Recurrence, Local/prevention & controlABSTRACT
In our animal experiments we used a chemical agent (dibutylnitrosamine) to induce urinary bladder tumor in rats, then this was implanted under the dorsal skin of rats of the same strain to gain a standard tumor preparation. The histological effects of electrocoagulation and Nd-Yag laser coagulation were compared in rat striated muscle, liver, intact rat urinary bladder and in our standard tumor preparation. The histological changes suggested that laser coagulation has advantages over electrocoagulation for inducing deep and homogenous necrosis in intact and tumorous tissues.
Subject(s)
Carcinoma, Transitional Cell/surgery , Electrocoagulation , Laser Coagulation , Urinary Bladder Neoplasms/pathology , Urinary Bladder Neoplasms/surgery , Animals , Carcinoma, Transitional Cell/chemically induced , Carcinoma, Transitional Cell/pathology , Female , Neoplasm Transplantation , Rats , Rats, Inbred F344 , Urinary Bladder Neoplasms/chemically inducedABSTRACT
Authors describe a new analytical method for monitoring the treatment of vesicular tumors. Chromatographic analysis of the polyamine content of the eluent allows differential diagnostic judgement of the malignity of the laser treated tumorous tissue. The practical applicability of the method is demonstrated and evaluated on the basis of the analysis of 88 clinical cases.
Subject(s)
Biogenic Polyamines/analysis , Carcinoma, Transitional Cell/chemistry , Carcinoma, Transitional Cell/surgery , Laser Therapy , Urinary Bladder Neoplasms/chemistry , Urinary Bladder Neoplasms/surgery , Aged , Chromatography, High Pressure Liquid , Female , Humans , Male , Middle Aged , Putrescine/analysis , Spermidine/analysis , Spermine/analysisSubject(s)
Laser Therapy , Urinary Bladder Neoplasms/surgery , Humans , Hungary , Laser Therapy/instrumentationABSTRACT
The urological complications of surgical interventions are discussed on the basis of the authors' clinical material collected over six years. Mainly fistulas and inflammatory complications occurred due to gynaecological operations performed by abdominal penetration. The possibilities and incidence of complications, as well as the diagnostic methods used for their detection and the applied therapies are reviewed. The importance of the proper choice of restituting surgical interventions is stressed. Complete anatomical and functional restoration and preservation of the organ are attempted. Attention is called to the importance and possibilities of preventing complications due to injuries. In the reduction of the incidence of urological complications after gynaecological operations, beside prevention, a close co-operation with the urologist is necessary as well as post-operative check-ups even in symptomless cases.
