[Epidemiological data of Hungarian skiers' and snowboarders' medical problems]. / A magyar alpesi sízok és hódeszkázók egészségkárosodásainak összehasonlító statisztikai elemzése.

INTRODUCTION AND AIM: There are no high mountains or any advantageous circumstances for winter sports in Hungary, yet within the 10 million population there are about half a million people (the exact number is 550,000) who tend to go for skiing or snowboarding abroad. Authors compared the injury statistical data with results described in the international literature in order to develop conclusions about the differences in the injury patterns and frequency between the Hungarian ones' and those found in countries with plenty of winter sport possibilities. METHOD: Authors analysed the winter sport injury cases of an insurance company. All the injury happened abroad and the assistance provider of the insurance company has managed the patient treatment and repatriation. Three winter seasons (12 months) data was analysed from the point of view of injuries frequency at different body parts and areas. Due to the fact that only limited information was available a simple statistical method was applied. RESULTS: Of 222 cases 90.5% were ski-related injury and 8.6% were snowboard injury. As for the skiers, the upper limb injuries accounted for 21.9%, the truncal region for 24.4% and the lower limb for 55.8%. Among snowboarders the upper limb injuries accounted for 36.9%, the truncal region for 37% and the lower limb for 26.1%. The most frequent was the knee (36.8%), the wrist (12.4) and the shoulder (11.4) injury. Skier's thumb injury was only 1.5%. The most common snowboard injury was the wrist trauma (31.6%), the head/neck/face was accounted 15.8% of all the injuries. And the ankle was injured in 10.5% of all the cases. The head/neck and the knee injury often combined with injuries of some other body part. 29 patients (13%) had to be repatriated, the most frequent reason for the repatriation was the injury of the lower limb. CONCLUSIONS: The Hungarian sportsmen's injury patterns do not always follow data described in the international literature, but they correspond to data of countries with similar geographical situation. The injury rate of knee and of the shoulder displays same data, the injury rate of the wrist was more frequent than in the international data, and this is true both for skiers and the snowboarders. The Hungarians' injury of the truncal region (mainly the head) was more frequent, but on the other hand the general injury rate of other body parts proved to be a lower number. It seems that the frequent use of the protective equipment and the preventive measures applied by the Hungarians are mirrored in the lower injury figures. Orv. Hetil., 2017, 158(16), 618-624.

Hematological and hemostaseological alterations after warm and cold limb ischemia-reperfusion in a canine model.

PURPOSE: Acute ischemia-reperfusion (I/R) of extremities means serious challenge in the clinical practice. Furthermore, the issue of preventive cooling is still controversial. In this canine model we investigated whether limb I/R -with or without cooling- has an influence on hematological and hemostaseological factors. METHODS: Femoral vessels were exposed and clamped for 3 hours. After release the clamps, 4-hour reperfusion was secured. The same procedures with cooling using ice bags, as well as warm and cold sham-operations were performed. Before operations, from the excluded limb by the end of ischemia, during the reperfusion, and for 5 postoperative days afterwards blood samples were collected for testing hematological and blood coagulation parameters. RESULTS: After I/R activated partial thromboplastin time was elongated on 2nd-4th postoperative days. The highest values were on the 2nd day in cold I/R group, accompanied by increased prothrombin time values. The hematological parameters and fibrinogen level showed non-specific changes. In excluded ischemic limb the blood composition showed controversial data. Cold ischemia induced larger alterations, however platelet count, hematocrit changed more expressly in warm ischemia. CONCLUSION: These results indicate the risk of coagulopathy following limb I/R on early post-eventually days, which risk is higher in the case of cold I/R.

Hematological and hemostaseological alterations after warm and cold limb ischemia-reperfusion in a canine model / Alterações hematológicas e hemostaseológicas após isquemia-reperfusão morna e fria de membro inferior em modelo canino

PURPOSE: Acute ischemia-reperfusion (I/R) of extremities means serious challenge in the clinical practice. Furthermore, the issue of preventive cooling is still controversial. In this canine model we investigated whether limb I/R -with or without cooling- has an influence on hematological and hemostaseological factors. METHODS: Femoral vessels were exposed and clamped for 3 hours. After release the clamps, 4-hour reperfusion was secured. The same procedures with cooling using ice bags, as well as warm and cold sham-operations were performed. Before operations, from the excluded limb by the end of ischemia, during the reperfusion, and for 5 postoperative days afterwards blood samples were collected for testing hematological and blood coagulation parameters. RESULTS: After I/R activated partial thromboplastin time was elongated on 2nd-4th postoperative days. The highest values were on the 2nd day in cold I/R group, accompanied by increased prothrombin time values. The hematological parameters and fibrinogen level showed non-specific changes. In excluded ischemic limb the blood composition showed controversial data. Cold ischemia induced larger alterations, however platelet count, hematocrit changed more expressly in warm ischemia. CONCLUSION: These results indicate the risk of coagulopathy following limb I/R on early post-eventually days, which risk is higher in the case of cold I/R.

OBJETIVO: Isquemia-Reperfusão aguda (I/R) de extremidades representa um desafio sério na prática clínica. Além disso, o tema de prevenção pelo resfriamento é ainda controverso. Nesse modelo canino, investigou-se se I/R de membros -com ou sem resfriamento- tem influência nos fatores hematológicos e hemostaseológicos. MÉTODOS: Os vasos femorais foram expostos e clampeados por 3 horas. Após liberação dos clampes, foi realizada a reperfusão por 4-horas. Os mesmos procedimentos com e sem resfriamento usando bolsas de gelo, assim como operações simuladas com e sem resfriamento foram realizados. Antes das operações, do membro excluído ao final da isquemia, durante a reperfusão e por 5 dias de pós-operatório, amostras sanguíneas foram colhidas para exames hematológicos e parâmetros de coagulação. RESULTADOS: Após I/R, o tempo de tromboplastina parcial ativada foi alargado no 2º.-4º. dias de pós-operatório. Os valores mais altos foram no 2º.dia no grupo deI/R fria, acompanhada pelo aumento dos valores do tempo de protrombina. Os parâmetros hematológicos e o nível de fibrinogênio mostraram mudanças não específicas. No membro isquêmico excluído a composição sanguínea mostrou dados controversos. A isquemia fria induziu maiores alterações, entretanto, a contagem de plaquetas e o hematócrito mudaram mais expressivamente na isquemia morna. CONCLUSÃO: Estes resultados indicam risco de coagulopatia após I/R de membros nos dias mais precoces após o evento, sendo mais elevado no caso da I/R fria.

Early systemic effects of hind limb ischemia-reperfusion on hemodynamics and acid-base balance in the rat.

We investigated the systemic hemodynamic effects and the early arteriovenous acid-base changes after 2-h tourniquet ischemia on left hind limb in rats during the first hour of reperfusion. The right femoral artery and vein were prepared and catheterized for direct blood pressure monitoring and blood sampling. In ischemia-reperfusion group, 5 min before releasing the tourniquet and during the first hour of the reperfusion (5', 10', 15', 30', 45', and 60'), arterial and venous blood samples were taken in parallel with a sham operated control group. In the ischemia-reperfusion group venous pH continuously decreased during reperfusion and was significantly lower compared to control and base in the 60th min, while arterial pH remained almost unchanged. PCO2 and pO2 showed moderate signs of a parallel respiratory compensation. Mean arterial pressure decreased almost by 20%, heart rate slightly increased during reperfusion. Our data indicates that besides the general effects anesthesia, limb ischemia-reperfusion results in hemodynamic and acid-base changes during the first hour of reperfusion.

Allopurinol prevents erythrocyte deformability impairing but not the hematological alterations after limb ischemia-reperfusion in rats.

The measurement of red blood cell deformability provides a possible method for detecting the effect of ischemia-reperfusion on erythrocytes. In our study the effect of 1-h ischemia-reperfusion with or without allopurinol pretreatment on hematological parameters and red blood cell deformability was investigated in a follow-up experiment of 26 male CD outbred rats that were subjected to unilateral hind-limb ischemia by microvascular clips on femoral vessels for 1 h (IR, n = 6), some rats received allopurinol pretreatment under the same conditions (50 mg/kg, AP + IR, n = 8), others were subjected to sham operation (n = 6), and the rest of animals served as control (n = 6). Measurement of erythrocyte deformability using a bulk filtrometer with special setting of cell suspension hematocrit (1%), and determination of hematological parameters were performed daily for one week. In the IR group, relative cell transit time increased significantly on postoperative days 1 and 2, which was not observed in the other groups. Settings for the measurement of erythrocyte deformability by reducing the blood sample volume gave the possibility of monitoring the resulting changes in rats. Mean corpuscular volume and hemoglobin, platelet count, and platelet volume were higher in the IR and AP + IR groups than in the other groups. In summary, short-term ischemia and reperfusion induced lower red blood cell deformability in the early postoperative period, which could be prevented by allopurinol pretreatment.

[Experimental "functional amputate model" in ischemia-reperfusion]. / Kísérletes "funkcionális amputációs modell" lehetosége az ischaemiareperfusio tükrében.

Limb amputation and ischemia-reperfusion (I/R) after trauma is a serious challenge, though there are few laboratory parameters that are available to predict the prognosis. It is even less so when possible adverse effects of preventive cooling may also influence the clinical outcome. We performed an experimental model earlier on mongrel dogs to investigate the local and systemic effects of cooled and non-cooled limb I/R. In this paper we describe the model and summarize the informative laboratory results. In the warm I/R group the femoral vessels were separately clamped for 3 hours, while steel-loop tourniquet for 7 hours was performed under the femoral vessels around the thigh. After ischemia releasing the clamps provided reperfusion for 4 hours then the steel-loop was removed. In the cooled I/R group similar procedure was performed but with cooling by ice bags. Cooled and non-cooled sham-operated groups also were used. Before operations, during the reperfusion and for 5 days blood samples were collected then haematology and chemistry parameters were determined. Blood rheology and certain coagulation factors were significantly different between the cool and non-cool ischemia-reperfusion groups, furthermore, the changes were also significant compared to sham-operated animals, suggesting that these parameters may be useful in the prognosis.

[The importance of hemorheological examinations in experimental limb ischemia-reperfusion injuries]. / A haemorheologiai vizsgálatok jelentosége kísérletes végtagi ischaemiareperfusiós károsodások kapcsán.

Rheological properties of the blood are determined by several factors and if they change it may be diagnostic for many diseases. It is well-known that during ischemia and reperfusion different free-radical liberating pathways are inducted besides the local physical and metabolical changes. These processes may harm red blood cells by increasing their rigidity and impairing their deformability. In ischemia-reperfusion models measurements of erythrocyte deformability is important. Characteristic alterations were observed in both rat and dog hind limb ischemia-reperfusion with vascular clamping on femoral vessels for 1 or 3 hours. Erythrocyte deformability was significantly impaired on the postoperative 1st-3rd days. The acute limb ischemia-reperfusion experimental models seem suitable for further in vivo rheological studies.