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Chem Rec ; 16(3): 1018-33, 2016 06.
Article in English | MEDLINE | ID: mdl-26997251

ABSTRACT

There is a great need for effective transformations and a broad range of novel chemical entities. Continuous-flow (CF) approaches are of considerable current interest: highly efficient and selective reactions can be performed in CF reactors. The reaction setup of CF reactors offers a wide variety of possible points where versatility can be introduced. This article presents a number of selective and highly efficient gas-liquid-solid and liquid-solid reactions involving a range of reagents and immobilized catalysts. Enantioselective transformations through catalytic hydrogenation and organocatalytic reactions are included, and isotopically labelled compounds and pharmaceutically relevant 1,2,3-triazoles are synthesized in CF reactors. Importantly, the catalyst bed can be changed to a solid-phase peptide synthesis resin, with which peptide synthesis can be performed with the utilization of only 1.5 equivalents of the amino acid.


Subject(s)
Triazoles/chemistry , Alkaloids/chemical synthesis , Alkaloids/chemistry , Catalysis , Heterocyclic Compounds/chemical synthesis , Heterocyclic Compounds/chemistry , Hydrogenation , Solid-Phase Synthesis Techniques , Stereoisomerism , Triazoles/chemical synthesis
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