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Synthesis of DNA-oligonucleotides damaged by arylamine-modified 2'-deoxyguanosine.

Böge, N; Szombati, Z; Meier, C.

Nucleosides Nucleotides Nucleic Acids ; 26(6-7): 705-8, 2007.

Article in English | MEDLINE | ID: mdl-18066884

ABSTRACT

C8-Arylamine-dG adducts bearing a labile N-formamidine group at the exocyclic amino function were converted into their corresponding 5'-O-DMTr-3'-O-phosphoramidite-C8-arylamine-dG derivatives. These compounds were used for the automated synthesis of site-specifically modified oligonucleotides. These oligonucleotides were characterized by ESI-MS and enzymatic digestion and studied for their CD properties and Tm values.

Subject(s)

Amines/chemistry , Aniline Compounds/chemistry , DNA Damage , DNA/chemical synthesis , Deoxyguanosine/chemistry , Oligonucleotides/chemical synthesis , Amides/chemistry , DNA Adducts/chemistry , Oligonucleotides/chemistry , Phosphoric Acids/chemistry

[The incidence and significance of congenital low body weight]. / A veleszületett soványság gyakorisága és jelentösége.

Berkö, P; Székhelyi, Z; Degrell, P; Hagymássy, L; Szombati, Z.

Orv Hetil ; 123(29): 1797-800, 1982 Jul 18.

Article in Hungarian | MEDLINE | ID: mdl-6890196

Subject(s)

Birth Weight , Fetal Growth Retardation/epidemiology , Female , Humans , Hungary , Infant, Low Birth Weight , Infant, Newborn , Infant, Small for Gestational Age , Pregnancy , Statistics as Topic

[Changes in the stages of cervical cancer as a result of cytological screenings]. / A cervix carcinoma stádiumainak változása a cytológiai szürések eredményeként.

Sótonyi, G; Szombati, Z; Argay, L.

Orv Hetil ; 121(35): 2133-4, 1980 Aug 31.

Article in Hungarian | MEDLINE | ID: mdl-7465174

Subject(s)

Uterine Cervical Neoplasms/pathology , Vaginal Smears , Female , Humans , Hungary , Mass Screening , Neoplasm Staging , Uterine Cervical Neoplasms/diagnosis

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