ABSTRACT
The sensitivity of haemophilus strains isolated from patients freshly were tested by newly produced fluorokinolones with broader antimicrobial activity and excellent pharmacokinetic features. We found a high sensitivity of all haemophilus strains tested by ofloxacin with Resistest method. The minimal inhibitory concentrations in Levinthal bouillon medium ranged between 0,015-0,03 micrograms/ml and the exerted a bactericidal effect. Since these concentrations are only a small portion of the blood and tissue levels of the ofloxacin, therefore the fluorokinolones proved to be effective antibacterial drugs in the therapy of the haemophilus infections.
Subject(s)
Drug Resistance, Microbial , Haemophilus/drug effects , Ofloxacin/pharmacology , Quinolones/pharmacology , Humans , In Vitro Techniques , PefloxacinABSTRACT
The analysis of the antigens produced by the disintegration of Staphylococcus aureus (Wood 46, 211, 223 strains) bacteria treated with antibiotics was carried out by the authors with immunochemical methods. It appears from the analyses strikingly that established resistance produces changes in the antigenic structure. This is manifest in the number of the antigen-antibody systems and, within the multiple system, in the character of certain antigens. The decrease in the number of the precipitogens is considerable. In the case of all the three strains, the presence of an antigen band was shown which is identical in the antibiotic-resistant bacteria, but is not to be found in the antigens of the corresponding antibiotic-sensitive bacteria. The authors' experience shows that one possibility of approaching the problem of antibiotic resistance is to clarify with immunochemical methods the differences found in the protein spectra of the antibiotic-resistant varieties.