ABSTRACT
Chorioangioma (chorionic angioma) is the most common non-malignant placental tumor Taking into account its morphological structure, it can have significant influence on fetal condition and pregnancy depending on its size. In the presented case a substantial placental tumor was diagnosed and complications typical for chorioangioma, such as fetal hemodynamic disorders, polyhydramnios, gestational diabetes and premature labor were observed. The applied treatment led to normalization of the fetal and maternal condition and to prolongation of the pregnancy
Subject(s)
Fetal Diseases/diagnosis , Hemangioma/diagnosis , Placenta Diseases/diagnosis , Polyhydramnios/diagnosis , Pregnancy Complications, Neoplastic/diagnosis , Adult , Diabetes, Gestational/diagnosis , Diabetes, Gestational/etiology , Female , Hemangioma/complications , Hemangioma/pathology , Hemangioma/therapy , Humans , Obstetric Labor, Premature/etiology , Placenta Diseases/pathology , Placenta Diseases/therapy , Polyhydramnios/etiology , Pregnancy , Pregnancy Complications, Neoplastic/pathology , Pregnancy Complications, Neoplastic/therapy , Young AdultABSTRACT
A case of a primigravida with hypovolemic shock symptoms and acute intrauterine fetal hypoxia was described. Emergency caesarean section, during which a hemorrhage to the peritoneal cavity caused by an unrecognized splenic artery aneurysm rupture was diagnosed, was immediately performed.
Subject(s)
Aneurysm, Ruptured/surgery , Obstetric Labor Complications/surgery , Pregnancy Complications, Cardiovascular/surgery , Rupture, Spontaneous/surgery , Splenic Artery/surgery , Adult , Aneurysm, Ruptured/diagnosis , Cesarean Section , Female , Humans , Infant, Newborn , Obstetric Labor Complications/diagnosis , Pregnancy , Pregnancy Complications, Cardiovascular/diagnosis , Pregnancy Trimester, Third , Rupture, Spontaneous/diagnosis , Splenectomy , Splenic Artery/pathologyABSTRACT
Thanatophoric dysplasia was first described in 1967 by Maroteaux. It is one of the most common lethal neonatal dwarfisms. Estimated incidence of thanatophoric dysplasia is 0.2-0.5 per 10,000 births. In the following report we have described a prenatally diagnosed case of recurrent thanatophoric dysplasia in the same patient.
Subject(s)
Pedigree , Pregnancy Trimester, Second/genetics , Thanatophoric Dysplasia/diagnostic imaging , Thanatophoric Dysplasia/genetics , Fatal Outcome , Female , Humans , Pregnancy , Ultrasonography, PrenatalABSTRACT
Holoprosencephaly is a brain malformation caused by abnormal division of the forebrain into two separate hemispheres. Abnormal structures of the central nervous system often occur with other midline forebrain and face failures. In this report we present a case of a prenatal diagnosis of holoprosencephaly.
Subject(s)
Holoprosencephaly/diagnostic imaging , Holoprosencephaly/embryology , Ultrasonography, Prenatal , Adult , Fatal Outcome , Female , Humans , Infant, Newborn , Pregnancy , Pregnancy Trimester, ThirdABSTRACT
Smith-Lemli-Opitz syndrome (SLOS) is a hereditary, autosomal recessive abnormality of cholesterol metabolism, leading to malformations of multiple organs. It is probably one of the most frequent metabolic disorders but variable clinical presentation makes the diagnosis of the syndrome difficult. The authors of the following work present a case report of prenatal diagnosis of SLOS in fetus with malformations of multiple organs and negative family history.
Subject(s)
Fetal Diseases/diagnosis , Prenatal Diagnosis/methods , Smith-Lemli-Opitz Syndrome/diagnosis , Fatal Outcome , Female , Fetal Diseases/genetics , Humans , Infant, Newborn , Pregnancy , Smith-Lemli-Opitz Syndrome/geneticsABSTRACT
The aim of the present study was to evaluate the oxidative status in healthy full-term children and piglets. Urinary excretion of 8-oxoGua (8-oxoguanine) and 8-oxodG (8-oxo-2'-deoxyguanosine) were determined using HPLC/GS/MS methodology and concentrations of vitamins A, C and E with HPLC technique. The levels of 8-oxoGua in urine samples were about 7-8 times higher in newborn children and piglets when compared with the level of adult subjects, while in the case of 8-oxodG the difference was about 2.5 times. The levels of vitamin C and E in umbilical cord blood of newborn children significantly depend on the concentration of these compounds in their mother's blood. However, the values of vitamin C in human's cord blood were about 2-times higher than in respective mother blood, while the level of vitamin E showed an opposite trend. The results suggest that: (i) healthy, full-term newborns are under potential oxidative stress; (ii) urinary excretion of 8-oxoGua and 8-oxodG may be a good marker of oxidative stress in newborns; and (iii) antioxidant vitamins, especially vitamin C, play an important role in protecting newborns against oxidative stress.
Subject(s)
Ascorbic Acid/urine , Deoxyguanosine/analogs & derivatives , Guanine/analogs & derivatives , Oxidative Stress , Vitamin E/urine , 8-Hydroxy-2'-Deoxyguanosine , Animals , Animals, Newborn , Antioxidants/analysis , Biomarkers/urine , Chromatography, High Pressure Liquid , Deoxyguanosine/urine , Female , Guanine/urine , Humans , Infant, Newborn , Male , Mass Spectrometry , SwineABSTRACT
The aim of the study was the estimation of hearing and the analysis of the risk factors for hearing loss in infants treated in neonatal intensive care units. The examinations were performed in 287 infants, who we examined in ENT Department between the ages of three and six months after discharge from neonatal intensive care unit. The infants were investigated with the use of ABR elicited with clicks and tone burst of 500 and 1000 Hz. Elevated auditory thresholds were found in 48 neonates in the first examination and in 27 in the second examination. Among the risk factors we observed the most frequently: gestational age < 33 Hbd, birth weight < 1500 g, respiratory and cardiovascular disorders and intracranial haemorrhages.
