Subject(s)
Aspergillosis/complications , Aspergillus fumigatus , Cytomegalovirus Infections/complications , Dermatomycoses/pathology , Leg Dermatoses/pathology , Lung Diseases, Fungal/complications , Skin Diseases, Viral/complications , Aspergillosis/pathology , Cytomegalovirus Infections/pathology , Dermatomycoses/complications , Female , Humans , Immunocompromised Host , Leg Dermatoses/microbiology , Middle Aged , Skin Diseases, Viral/pathologyABSTRACT
A major topic covered at the First International Symposium on Cancer Metastasis and the Lymphovascular System was the molecular mechanisms of metastasis. This has become of major interest in recent years as we have discovered new metastasis-related genes and gained understanding of the molecular events of lymphatic metastasis. The symposium covered new aspects and important questions related to the events of metastasis in both humans and animals. The basic and clinical related research covered in this topic represented many disciplines. The presentations showed novel findings and at the same time, raised many new unanswered questions, indicating the limited knowledge we still have regarding the molecular events of metastasis. The hope is that further unraveling of the direct and indirect molecular events of lymphatic metastasis will lead to new approaches in developing effective therapeutics.
Subject(s)
Lymphatic Metastasis/physiopathology , Lymphatic System/physiopathology , Neoplasm Metastasis/physiopathology , Animals , Humans , Lung Neoplasms/pathology , Lung Neoplasms/physiopathology , Lymphatic Metastasis/pathology , Melanoma/drug therapy , Melanoma/pathology , Melanoma/physiopathology , Microscopy, Video , Neoplasm Metastasis/pathology , Oncogenes/physiology , Receptors, Chemokine/physiology , Signal Transduction , Vascular Endothelial Growth Factor C/physiologyABSTRACT
The glomus coccygeum is a vestigial structure related to the canals of Sucquet-Hoyer, an arteriovenous anastomosis surrounded by glomus cells derived from modified smooth muscle and involved in thermoregulation. It is an incidental finding in specimens from the sacral area and may represent a diagnostic challenge to the unaware observer. We present a case of a glomus coccygeum, presenting as a 1.5-mm structure adjacent to a typical pilonidal cyst excised from a 7-month-old boy, which was the subject of a second opinion consultation. The lesion showed small to medium sized clusters of predominantly epithelioid cells with moderate amounts of clear to eosinophilic cytoplasm, intercellular borders, and plump, round nuclei with fine chromatin. These cells were closely associated with small vascular channels and nerves. Immunohistochemistry revealed that the epithelioid cells expressed vimentin, muscle-specific actin, neuron-specific enolase, and S-100 protein, were weakly positive for smooth muscle actin, and negative for desmin, synaptophysin, and chromogranin. The endothelial cells of the vascular channels were antibody CD31 positive. Recognition of the histologic features of glomus coccygeum is important to avoid confusion with glomus tumor and neural or smooth muscle neoplasms in the sacral area.
Subject(s)
Arteriovenous Anastomosis/pathology , Pilonidal Sinus/pathology , Sacrococcygeal Region/pathology , Arteriovenous Anastomosis/metabolism , Diagnosis, Differential , Glomus Tumor/pathology , Humans , Immunohistochemistry , Infant , Male , Smooth Muscle Tumor/pathologyABSTRACT
Phakomatous choristoma is a rare congenital hamartoma of lens tissue. It presents in newborns or young infants as a subcutaneous mass in the medial lower eyelid. We present a case of phakomatous choristoma recently identified among old consultation files at Children's Hospital in Boston. Our case illustrates unique histological features of this entity which has to be included in differential diagnosis of skin lesions of the inferonasal eyelid.
