1.
Arch Geschwulstforsch
; 59(4): 257-63, 1989.
Article
in German
| MEDLINE
| ID: mdl-2802933
ABSTRACT
The nitrosatability of Pryleugan (imipramine), Herphonal (trimipramine), and Finlepsin (carbamazepine) was investigated under simulated human gastric conditions using a colorimetric measuring method. All of them proved to be nitrosatable even at very low nitrite concentrations. In the presence of ascorbic acid, the formation of N-nitroso compounds under model conditions was inhibited markedly. N-nitroso-dihydrodibenzazepine and N-nitroso-dibenzazepine could be identified by thin layer chromatography as main products. The biological effects of these N-nitroso compounds are not known up to now.
Subject(s)
Carbamazepine/metabolism , Dibenzazepines/metabolism , Gastric Mucosa/metabolism , Imipramine/metabolism , Nitroso Compounds/metabolism , Trimipramine/metabolism , Dibenzazepines/analysis , Humans , In Vitro Techniques , Nitrites/administration & dosage , Nitrites/metabolism , Nitrosamines/analysis , Nitrosation
2.
J Rehabil
; 42(2): 19-22, 1976.
Article
in English
| MEDLINE
| ID: mdl-1255649