ABSTRACT
The authors give a common survey of clinical and pathological appearance of cysts of maxillary sinuses, especially their dental origin. They review the possibilities of diagnosis and show the treatment technic they used the past 4 years on 11 cases. They emphasise the importance of radiological controlling the root canal treated teeth and the role of the dentist in instructing the patient about this.
Subject(s)
Cysts , Maxilla/pathology , Maxillary Sinus/pathology , Tooth Diseases , Adult , Cysts/complications , Cysts/diagnostic imaging , Cysts/pathology , Cysts/therapy , Facial Pain/etiology , Female , Humans , Male , Middle Aged , Patient Education as Topic , Tomography, X-Ray Computed , Tooth Diseases/complications , Tooth Diseases/diagnostic imaging , Tooth Diseases/pathology , Tooth Diseases/therapyABSTRACT
The results gained with the treatment of benzylalcohol and amyl-m-cresol tablets in oral inflammatic diseases (153 cases) and in the prophylaxis of possible infections (119 cases) accompanied with surgical interventions has been summarised. It was concluded that, the average healing process shortened by 30% in time, and the quality parameters (pain, function etc.) showed 30% better results in 78.4% of the cases treated with Strepsils. 88.3/ of patients preferred to get the tablets, the tolerability was excellent. The two third of the patients suffering from inflammatory diseases reported reduction of the pain within the first 60 minutes after the very first tablet application. The experience gained with 272 patients showed very good effectivity especially in the cases aphtha, gingivostomatitis herpetica, stomatitis mycotica, gingivitis, denture stomatitis, erythema exsudativum multiforme, stomatopharyngitis, periodontitis. The drug has showed of remarkable result in the prophylaxis of periodontal, dentoalveolar, implant, soft tissue, maxillofacial surgical interventions.
Subject(s)
Anti-Infective Agents, Local/therapeutic use , Benzyl Alcohol/therapeutic use , Cresols/therapeutic use , Stomatitis/drug therapy , Adolescent , Adult , Female , Humans , Male , Middle Aged , Stomatitis/etiology , Stomatitis/prevention & control , Stomatitis, Aphthous/drug therapy , Stomatitis, Denture/drug therapy , Stomatitis, Herpetic/drug therapy , Treatment OutcomeABSTRACT
In 114 patients suffering from dental inflammatory diseases (periostitis, gingivitis, sinusitis, periodontitis etc.) and in 41 cases of dental surgical procedures (implantation, dentoalveolar surgery etc.) 3 x 300 mg/day clindamycin was applied during 7 days in the framework of GCP phases IV. In 150 cases (97%) the product proved to be effective and only in 2 cases a mild side effect was observed. On the base of the results clindamycin can be advised for the treatment of stomatological diseases.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Clindamycin/therapeutic use , Mouth Diseases/drug therapy , Oral Surgical Procedures , Aminoglycosides , Anti-Bacterial Agents/administration & dosage , Bacterial Infections/drug therapy , Clindamycin/administration & dosage , Drug Administration Schedule , Female , Humans , Inflammation , Male , Mouth Diseases/microbiology , Treatment OutcomeABSTRACT
The authors summarised the literature data of benzylalcohol and amyl-m-cresol. In the clinical practice they used Strepsils in the treatment of 22 patients suffered from oral inflammatic diseases and in the 20 prophylactic cases of oral surgical interventions. The preliminary clinical report shows that, the Strepsils seems to be very effective in the treatment of oral inflammations and in the prophylaxis too.
Subject(s)
Benzyl Alcohol/therapeutic use , Cresols/therapeutic use , Gingivitis , Stomatitis/drug therapy , Adolescent , Adult , Anesthetics, Local , Cresols/administration & dosage , Double-Blind Method , Female , Gingivitis/drug therapy , Gingivitis/prevention & control , Humans , Male , Middle Aged , Placebos , Preoperative Care , Stomatitis/prevention & control , Surgery, OralABSTRACT
In this study roxithromycin was applied for prophylactic treatment of 104 patients (implantology, dentoalveolar surgery, risk patients etc.) underwent dental surgery. The efficacy and side effects of roxithromycin were studied. The efficacy of this antibiotic was 92%, gastrointestinal complains, as the most common side effects were obtained in 2.8% of the patients treated with roxithromycin.
Subject(s)
Anti-Bacterial Agents/administration & dosage , Roxithromycin/administration & dosage , Surgery, Oral , Adult , Dental Implantation , Female , Gastrointestinal Diseases/chemically induced , Humans , Male , Preoperative Care , Roxithromycin/adverse effectsABSTRACT
Reformulation of metered-dose inhalers (MDIs) without the use of chlorofluorocarbon (CFC) propellants presents numerous obstacles because there are no alternative propellants that can serve as immediate replacements for pharmaceutical use. Hydrofluorocarbons (HFCs), hydrochlorofluorocarbons (HCFCs) and hydrocarbons (HCs) are all under consideration as possible alternatives for CFC propellants. However, no single propellant or combination of propellants has been identified with all of the physical-chemical properties of CFCs. Based on their zero ozone depletion potentials, relatively low global warming potentials, non-flammabilities, densities, and vapor pressures, HFA-134a and HFA-227 are the most attractive replacement propellants identified to date. Yet, their use in MDIs will still require: (1) identification of a metering valve with propellant and formulation-compatible gaskets, (2) use of current suspending agents at levels much lower than in present MDIs or identification (and characterization) of new suspending agents, and (3) modification of existing manufacturing technologies. Demonstration of acceptable final product stability, safety and efficacy will be necessary prior to submission to worldwide registration authorities.
Subject(s)
Aerosol Propellants/standards , Hydrocarbons, Fluorinated/standards , Nebulizers and Vaporizers/standards , Administration, Inhalation , Aerosol Propellants/chemistry , Equipment Design , Humans , Hydrocarbons, Fluorinated/chemistryABSTRACT
Theoretical models for percutaneous penetration are described, and a diffusion apparatus useful in the evaluation of transport kinetics of drugs applied to skin is discussed. Experimental data are presented for: (a) the flux of diflorasone diacetate through hairless mouse skin, (b) the percutaneous penetration profile of propylene glycol, (c) the effects of vehicle concentrations of polyoxypropylene 15 stearyl ether and propylene glycol on the percutaneous flux of diflorasone diacetate, (d) skin--vehicle partition coefficients of diflorasone diacetate, (e) the solubility profile of diflorasone diacetate as a function of solvent concentration, and (f) the alteration of the skin's resistance to the penetration of diflorasone diacetate due to propylene glycol. Excess solvent in a vehicle caused a decrease in the percutaneous flux of diflorasone diacetate. Formulations containing 0.05 and 0.1% diflorasone diacetate had similar penetration rates when the solvent concentration was optimized for each percentage of diflorasone diacetate.
Subject(s)
Anti-Inflammatory Agents/metabolism , Polymers/pharmacology , Propylene Glycols/pharmacology , Skin Absorption/drug effects , Administration, Topical , Animals , Anti-Inflammatory Agents/administration & dosage , Betamethasone/analogs & derivatives , Female , Glucocorticoids , In Vitro Techniques , Kinetics , Mice , Mice, Nude , Models, Biological , Ointments , Pharmaceutical Vehicles , SolubilityABSTRACT
The kinetics of uptake and release of desmosterol, cholesterol, and beta-sitosterol by Burkitt lymphoma cells at 26 degrees, pH 7.3, and isoosmotic conditions were quantitatively and mechanistically interpreted. The data are in agreement with the model involving the passive transport of the unbound sterol across the rate-determining plasma membrane, with rapid distribution within the heterogeneous cell interior. Effective permeability (P-e) and partition (K-e) coefficients of the sterols were inversely proportional to the serum concentration in the external media due to sterol-serum binding. These results are consistent with the mechanism in which only the unbound solute in the external solution participates in the membrane transport process. At all serum levels, P-e and K-e increased with increasing sterol polarity: desmosterol greater than cholesterol greater than beta-sitosterol.
Subject(s)
Cell Membrane Permeability , Cholesterol/metabolism , Desmosterol/metabolism , Sitosterols/metabolism , Animals , Burkitt Lymphoma , Cattle , Cells, Cultured , Fetus , Kinetics , Models, Biological , Permeability , Regression AnalysisABSTRACT
General physical models are derived for the diffusional transport of drugs across membranes of mammalian cells in culture suspension. These models represent different sets of possible physical processes taking place during the transport of a drug molecule. Once the diffusing species reaches the cell barrier, it may gain entrance to the cell kinetically by one of the principal quasisteady-state mechanisms, all of which assume the cell membrane to be an integral part of the total barrier.
Subject(s)
Cell Membrane Permeability , Biological Transport , Cell Membrane , Cells, Cultured , Diffusion , Models, Biological , Pharmaceutical Preparations/blood , Subcellular Fractions/metabolismABSTRACT
Mass transport studies with three cardiac glycosides in the Burkitt lymphoma cell system have provided significant examples of the factorization and quantification of the influences of serum-drug binding, membrane-drug binding, cell interior binding, and intrinsic membrane permeability upon the uptake and release kinetics of drugs in living cell systems. All of the data from the glycosides are in agreement with the general physical model involving the rapid equilibration of the solute within the cell after permeation through the rate-determining plasma membrane barrier. The transport of digitoxin was influenced by membrane and serum binding and that of digoxin was influenced by membrane binding. There was no binding of ouabain to the plasma membrane and serum. The variables in the uptake and release kinetic studies at pH 7.3 included the use of viable and heat-inactivated cells, fetal bovine serum levels, and temperature.
