ABSTRACT
BACKGROUND: This study was conducted to dosimetrically compare plan quality of Simultaneous Integrated Boost - Stereotactic Body Radiotherapy (SIB-SBRT) generated for different techniques such as Cyberknife (CK), Helical Tomotherapy (HT) and RapidArc (RA) for carcinoma prostate with same treatment margins. MATERIALS AND METHODS: SIB-SBRT plans were generated for CK, HT and RA for thirteen CT data sets. The dose prescription was 45Gy in 5 fractions to GTV45 and 37.5Gy in 5 fractions to PTV37.5. The plan quality evaluation of the three techniques was done by comparing the DVH parameters, conformity index (CI) and gradient index (GI). For OAR's mean, maximum dose and dose volumes were compared for bladder, rectum and bilateral femoral heads. The number of Monitor Units (MU) delivered and Beam-on time (BOT) were also compared. RESULTS: D2%, D50% and DMean to GTV45 was significantly higher in the CK compared to HT and RA (CK vs HT: p values, <0.001, 0.002 and 0.003; CK vs RA: p values, 0.001, 0.004 and 0.004) respectively. RA gives a better gradient index compared to CK and HT. Conformity indices of the RA plans were better than the CK plans (P<0.001). Normal tissue and integral dose delivered to the patient in HT and CK were found to be significantly higher than RA. The average number of MU's and BOT were significantly higher in CK (p<0.001). CONCLUSION: Using the same treatment margins and dose constraints, RA achieved better target dose distribution and sparing of critical structures compared to CK and HT. RA seemed to be the optimal planning technique for SIB-SBRT treatment of carcinoma prostate.
.
Subject(s)
Organs at Risk/radiation effects , Prostatic Neoplasms/radiotherapy , Prostatic Neoplasms/surgery , Radiosurgery/methods , Radiotherapy Planning, Computer-Assisted/methods , Radiotherapy, Intensity-Modulated/methods , Adenocarcinoma/pathology , Adenocarcinoma/radiotherapy , Adenocarcinoma/surgery , Follow-Up Studies , Humans , Male , Prognosis , Prostatic Neoplasms/pathology , Radiotherapy Dosage , Retrospective StudiesABSTRACT
OBJECTIVE: The study was conducted to quantitatively evaluate the dosimetric effects of high definition (2.5 mm) and standard definition (5.0 mm) MLC on the quality of SBRT plans using SIB-IMRT and SIB-VMAT technique for carcinoma prostate and also to evaluate the dosimetric advantage of one technique over the other. MATERIALS AND METHODS: Seventeen annonymized planning CT data sets were used to generate plans for both VMAT and IMRT techniques using 2.5 mm and 5.0 mm MLC.The prescription to the nodule was 45Gy in 5 fractions and to the prostate was 35Gy in 5 fractions.CI, GI, D2%, D98%, D50% and V95% for target; D2%, Dmean, V80%, V20% for OAR's; V5% of the irradiated volume, and delivered MU's were analyzed.An independent t-test was used to compare the plans. Patient specific QA for all plans were also performed and analyzed. RESULTS: Minor difference in dosimetric indices was observed between 2.5mm and 5mm MLC VMAT plans, except D2% (PTV35) and D98% (GTV45) were better in 2.5mm MLC plans (p.
