ABSTRACT
A hybrid congenic strain, C57BL/6J.SPRET-Hprt(a), carrying 17 map units of Chromosome (Chr) X from Mus spretus on a background of C57BL/6J. has the novel phenotype of low fertility associated with small testis weight. In histological cross-section, many of the tubules in the testes of these congenic mice are empty except for Sertoli cells, while the other tubules appear to be normal. The gene, interspecific hybrid testis weight 1 (Ihtw1) causing this phenotype, has been fine mapped by using the strategy of generating subcongenic strains from recombinants within the congenic region. Genetic and phenotypic analysis of the subcongenic strains has defined a critical region of 1.8 map units for Ihtw1. This region of the genetic map is orthologous to the region on human Chr X containing the gene for the Borjeson-Forssman-Lehman syndrome, an inherited disease in which males show microorchidism.
Subject(s)
Fertility/genetics , Testis/anatomy & histology , X Chromosome/genetics , Alleles , Animals , Chromosome Mapping , Crosses, Genetic , Female , Genetic Variation , Male , Mice , Mice, Congenic , Mice, Inbred C57BL , Organ Size , PhenotypeABSTRACT
Earthquake-induced liquefaction features in Holocene sediments provide evidence of strong prehistoric shaking, magnitude m(b) 6.2 to 6.7, in the Wabash Valley bordering Indiana and Illinois. The source of the one or more earthquakes responsible was almost certainly in or near the Wabash Valley. The largest event is interpreted to have occurred between 7500 and 1500 years ago on the basis of archeological, pedological, and stratigraphic relations.
