[Results of treatment of atypical endometrial hyperplasia]. / Rezultaty lecheniia atipicheskoi giperplazii éndometriia.

PIP: To evaluate the risk of transformation of atypical endometrial hyperplasia (AEH) into endometrial cancer, a group of 190 women who underwent treatment for AEH was followed up. The group included 53 women of child-bearing age, 81 in the premenopausal period, and 56 in the postmenopausal period. The most frequent clinical manifestation of AEH was metrorrhagia. The patients with mild or moderate AEH received conservative treatment, while the patients with severe AEH complicated by other gynecological diseases (uterine myoma or adenomyosis) received surgical treatment. Conservative hormonal treatment included cyclic administration of infecundin, bisecurin, hydroxyprogesterone caproate. The average duration of hormone therapy was 12 months. The 1st follow-up examination was conducted 3 months after the onset of the treatment. Of 53 patients of child-bearing age, 18 had recurrence of AEH (1 within 6 months after the initiation of the treatment, 5 within 6 months, 10 within 1-3 years, 1 within 5 years, and 1 within 9 years). Endometrial cancer was diagnosed in 2 patients (7 and 10 years after treatment of AEH). Of 81 patients in the premenopausal period, 29 developed recurrence of AEH within 3 months to 3 years of the treatment; endometrial cancer was detected in 2. Of 56 patients in the postmenopausal period, 16 developed recurrence within 3-6 months of the treatment; endometrial cancer was diagnosed in 3 patients. These findings indicate that majority of the patients with AEH can be cured by hormonal therapy, but the high risk of cancer development (3.7%) requires longterm follow-up.^ieng

[Evaluation of the local effect of cryosurgery in recurrent endometrial hyperplasia]. / K otsenke mestnogo éffekta kriokhirurgii pri retsidiviruiushchei giperplazii éndometriia.

A complex examination of the endometrium by cytomorphological methods, including impulse cytophotometry, radiometric monitoring and blood plasma-estradiol measurements was carried out in patients aged 41-54, to ascertain the local effect of cryosurgery performed for recurrent endometrial hyperplasia. The study was conducted in perimenopausal patients before and 4 months after cryosurgery. The results confirmed the high local effect of the treatment and showed DNA-histograms of the endometrium to provide a means of objective monitoring of treatment effectiveness.