ABSTRACT
Se reseñan los medicamentos evaluados y con dictamen positivo por comisión de expertos de la Agencia Española de Medicamentos y Productos Sanitarios o de la Agencia Europea del Medicamento hecho públicos en diciembre de 2014, enero y febrero de 2015, y considerados de mayor interés para el profesional sanitario. Se trata de opiniones técnicas positivas que son previas a la autorización y puesta en el mercado del medicamento
The drugs assessed by the Spanish Agency for Medicines and Health Products or European Medicines Agency made public in December 2014, January and February 2015, and considered of interest to the healthcare profesional, are reviewed. These are positive technical reports prior to the authorization and placing on the market of the product
Subject(s)
Humans , Drug Approval , Drug Evaluation , Drug and Narcotic Control/organization & administrationABSTRACT
Se reseñan los medicamentos evaluados y con dictamen positivo por comisión de expertos de la Agencia Española de Medicamentos y Productos Sanitarios o de la Agencia Europea del Medicamento hecho públicos en septiembre, octubre y noviembre de 2014, y considerados de mayor interés para el profesional sanitario. Se trata de opiniones técnicas positivas que son previas a la autorización y puesta en el mercado del medicamento
The drugs assessed by the Spanish Agency for Medicines and Health Products or European Medicines Agency made public in September, October and November of 2014, and considered of interest to the healthcare profesional, are reviewed. These are positive technical reports prior to the authorization and placing on the market of the product
Subject(s)
Humans , Male , Female , Drug Evaluation/legislation & jurisprudence , Drug Evaluation/methods , Drug Evaluation , Dermatitis, Phototoxic/epidemiology , Dermatitis, Phototoxic/prevention & control , Drug Evaluation/instrumentation , Drug Evaluation/trends , Evaluation of the Efficacy-Effectiveness of Interventions , Combined Modality Therapy/instrumentation , Combined Modality Therapy/methodsABSTRACT
Se reseñan los medicamentos ya evaluados por la Agencia Española de Medicamentos y Productos Sanitarios hechos públicos en junio, julio y agosto de 2014, y considerados de mayor interés para el profesional sanitario. Se trata de opiniones técnicas positivas que son previas a la autorización y comercialización del medicamento
The drugs assessed by the Spanish Agency for Medicines and Health Products made public in June, July and August of 2014, and considered of interest to the healthcare professional, are reviewed. These are positive technical reports prior to the autho-rization and placing on the market of the product
Subject(s)
Humans , Male , Female , Drug Evaluation , Drug Evaluation/ethics , Drug Evaluation/legislation & jurisprudence , Drug Therapy, Combination , Drug Therapy, Combination/instrumentation , Drug Therapy, Combination/psychology , Drug Evaluation/adverse effects , Drug Evaluation/trends , Drug Evaluation , Drug Therapy, Combination/trends , Drug Therapy, Combination , Pharmaceutical Preparations/administration & dosage , Pharmaceutical PreparationsABSTRACT
Se reseñan los medicamentos ya evaluados por la Agencia Española de Medicamentos y Productos Sanitarios hechos públicos en abril, mayo y junio de 2014, y considerados de mayor interés para el profesional sanitario. Se trata de opiniones técnicas positivas que son previas a la autorización y puesta en el mercado del medicamento
The drugs assessed by the Spanish Agency for Medicines and Health Products made public in April, May and June of 2014, and considered of interest to the healthcare professional, are reviewed. These are positive technical reports prior to the authorization and placing on the market of the product
Subject(s)
Humans , Drug Approval , Drug Evaluation , Drug Compounding , Investigational New Drug ApplicationABSTRACT
Se reseñan los medicamentos ya evaluados por la Agencia Española de Medicamentos y Productos Sanitarios hechos públicos en septiembre, octubre y noviembre de 2013, y considerados de mayor interés para el profesional sanitario. Se trata de opiniones técnicas positivas que son previas a la autorización y puesta en el mercado del medicamento
The drugs assessed by the Spanish Agency for Medicines and Health Products made public in September, October and November of 2013, and considered of interest to the healthcare professional, are reviewed. These are positive technical reports prior to the authorization and placing on the market of the product
Subject(s)
Humans , Drug Approval , Drug Evaluation , Drug Design , Drugs, InvestigationalABSTRACT
This study compared the biocompatibility in vitro and the osseointegration in vivo of zirconium and titanium implants regarding implant surfaces and the bone-implant contacts. The different implant surfaces and the biocompatibility of zirconium versus titanium implants were determined by vitality and cytotoxic tests in vitro. The contact of the osteoblasts to the implant surface was determined by scanning electron microscopy (SEM). The in vivo study for osseointegration was performed in domestic pigs over 4 and 12 weeks. In each animal, 4 zirconium and 4 titanium implants (WhiteSky, BlueSky, Bredent, Germany) were inserted in the os frontale and analysed by histomorphometry. Cytotoxicity and SEM showed good biocompatibility in relation to the investigated implant materials. Histological results showed direct bone-implant contact of the implant surfaces. The zirconium implants showed a slight delay in osseointegration in terms of bone-implant contact as measured by histomorphometry (after 4 weeks, zirconium (59.3 ± 4.6%) versus titanium (64.1 ± 3.9%); after 12 weeks, zirconium (67.1 ± 2.3%) versus titanium (73.6 ± 3.2%). A statistically significant difference between the two groups was not observed. The results indicated similar biocompatibility and osseointegration for zirconium compared to titanium implants.
Subject(s)
Biocompatible Materials/chemistry , Ceramics/chemistry , Dental Implants , Dental Materials/chemistry , Osseointegration/physiology , Titanium/chemistry , Zirconium/chemistry , Animals , Biocompatible Materials/toxicity , Bone Matrix/anatomy & histology , Bromodeoxyuridine , Cell Culture Techniques , Cell Proliferation/drug effects , Cell Survival/drug effects , Ceramics/toxicity , Coloring Agents , Dental Materials/toxicity , Dental Prosthesis Design , Female , Fluoresceins , Fluorescent Dyes , Frontal Bone/anatomy & histology , Frontal Bone/surgery , Humans , L-Lactate Dehydrogenase/analysis , Materials Testing , Microscopy, Electron, Scanning , Models, Animal , Osteoblasts/drug effects , Osteoblasts/ultrastructure , Osteocalcin/analysis , Swine , Tetrazolium Salts , Thiazoles , Time Factors , Titanium/toxicity , Zirconium/toxicityABSTRACT
Retropubic colposuspension (RC) is one of leading surgical treatments of stress enuresis in women. A low-traumatic method of RC with application of special surgical instruments is proposed. Retropubic urethrocervicopexy and low-invasive colposuspension were made in 27 and 17 women, respectively. 25 women have undergone endoscopic operations. Postoperative complications were minimal in endoscopic and low-invasive interventions. Long-term results were similar to literature data. Low-invasive colposuspension is an effective and low-traumatic treatment of stress enuresis in women.
Subject(s)
Surgical Instruments , Urinary Incontinence, Stress/surgery , Urologic Surgical Procedures/methods , Adult , Female , Humans , Middle Aged , Urinary Incontinence, Stress/pathologyABSTRACT
The authors provide information concerning an experimental model of a suturing instrument for the formation of linear biliodigestive anastomoses, by means off which the communications are created in different parts of the ducts, even the intrahepatic ducts, 5 mm or more in diameter. The instrument was used in operations on 29 patients who had cicatricial stenosis of the major duodenal papilla, carcinoma of the pancreas or ducts in the region of the porta hepatis. The instrument is universal in range and can be used for the creation of various types of biliodigestive anastomoses, it makes the operative techniques simpler and more reliable. Complications associated with the use of the instrument did not occur.
Subject(s)
Biliary Tract Surgical Procedures , Digestive System Surgical Procedures , Surgical Staplers , Aged , Anastomosis, Surgical , Bile Duct Neoplasms/surgery , Bile Ducts/surgery , Female , Gallbladder/surgery , Humans , Jejunum/surgery , Male , Middle Aged , Pancreatic Neoplasms/surgery , Stomach/surgerySubject(s)
Cholangitis/surgery , Cholelithiasis/surgery , Cholestasis, Extrahepatic/surgery , Adult , Aged , Female , Humans , Male , Middle Aged , Postoperative ComplicationsABSTRACT
The topography of the hepatic arteries in the lower half of the hepatoduodenal ligament was studied on 230 human cadavers. In 64.8% of cases the common hepatic artery was, as usual, in the left margin of the hepatoduodenal ligament, in 0.87% it was between the common bile duct and the portal vein i.e. to the right from the latter. The location of the right hepatic artery to the right or to the right and backwards from the common bile duct constitutes a supplementary risk of an accidental lesion of this artery in choledochotomy and drainage of the duct.
