ABSTRACT
The records of 52 consecutive patients who underwent surgical treatment for 57 episodes of hemodialysis graft infection (HGI) from 1977 to 1993 were reviewed to determine the mortality and morbidity associated with this complication and to clarify guidelines for its management. The study group consisted of 35 women and 17 men whose mean age was 57 years at initial graft placement. Thirty-three (58%) HGIs involved straight grafts in the upper arm, 12 (21%) straight forearm grafts, 11 (19%) loop forearm grafts, and 1 (2%) a loop groin fistula. All of these grafts were constructed with polytetrafluoroethylene (PTFE). All 57 cases of HGI showed at least local evidence and 41 (72%) caused systemic symptoms. Thirty-seven (65%) HGIs were associated with positive blood cultures. The predominant infecting organism was Staphylococcus, which was isolated alone or in combination with other organisms from 40 (70%) graft or would sites. Seventy-eight percent (31/40) of the staphylococcal infections involved Staphylococcus aureus. The median time from graft implantation to diagnosis of HGI was 7 months (mean 16 months, range 0 to 77 months) and from diagnosis to surgical treatment, 4 days (mean 6 days, range 0 to 26 days). Initial surgical management consisted of complete excision of all prosthetic material in 43 (75%) cases and partial excision in 14. The 30-day mortality rate following the last operation for the treatment of HGI was 12% (6/52) and was not significantly increased by incomplete excision. Six (86%) of the early deaths were related to sepsis and each of these patients had positive blood cultures.(ABSTRACT TRUNCATED AT 250 WORDS)
Subject(s)
Blood Vessel Prosthesis/adverse effects , Prosthesis-Related Infections/surgery , Renal Dialysis , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Polytetrafluoroethylene , Prosthesis-Related Infections/mortality , Retrospective Studies , Staphylococcal Infections/surgery , Survival RateABSTRACT
UNLABELLED: This study evaluated the strength of laser-welded arteriovenous shunts established using St. Jude BioPolyMeric vascular grafts. The arterial anastomoses of the biological graft were laser welded with and without the addition of soluble collagen or fibrin sealant. In four dogs, 16 arteriovenous grafts were implanted between the femoral artery and vein or the carotid artery and jugular vein using a 6 cm long, 4 mm internal diameter prosthesis. The 16 arterial anastomoses were evenly divided into four groups: sutured control, laser welded (LW), LW with soluble collagen applied immediately before and during welding, and LW with fibrin sealant applied after welding. All arterial control and venous anastomoses were sutured using continuous 6-0 polypropylene suture. All LW anastomoses were initially divided into six 5 mm long segments using six evenly spaced 6-0 polypropylene stay sutures. Each segment was laser welded using 15 to 18 5-sec pulses of the 0.5 W (7.5 W/cm 2) argon laser energy delivered via a 300 mum fiber while cooling the tissue with slow-drip saline irrigation. Blood flow was established and maintained through each anastomosis for 1 h. The vessels were then controlled, and anastomotic bursting pressure was determined with infusion of heparinized blood. RESULTS: An additional hemostatic suture was required in 3 LW anastomoses (2 LW, 1 LW with collagen). Mean bursting pressures (mm Hg) of the arterial anastomoses were as follows: sutured controls 165 +/- 159, LW 144 +/- 58, LW and collagen 93 +/- 47, LW and fibrin sealant 181 +/- 45.(ABSTRACT TRUNCATED AT 250 WORDS)
Subject(s)
Arteriovenous Shunt, Surgical/methods , Blood Vessel Prosthesis , Fibrin Tissue Adhesive/therapeutic use , Laser Therapy/methods , Suture Techniques , Animals , Argon , Arteriovenous Shunt, Surgical/adverse effects , Arteriovenous Shunt, Surgical/instrumentation , Blood Vessel Prosthesis/methods , Cattle , Collagen/therapeutic use , Dogs , Evaluation Studies as Topic , Materials Testing , Prosthesis Design , Venous PressureABSTRACT
This study reports three-dimensional reconstruction of two-dimensional intravascular ultrasound images obtained along 5 cm vessel segments. Each three-dimensional image was produced by computerized "stacking" of a set of consecutive two-dimensional images (mode 90 images per set; range 32 to 256). Three-dimensional images (n = 26) were obtained from 11 human normal and atherosclerotic arteries (three in vitro and eight in vivo) and five in vivo canine studies. In vivo human examinations included three iliac, one deep, and three superficial femoral arteries and one aortic dissection. Five in vivo canine vessels (three iliac stenoses and two aortic dissections) were imaged before and after intraluminal stent deployment. Images were displayed on a gray-scale monitor, allowing examination of vessel images as complete cylinders or longitudinal hemisections in any user-defined plane. This enabled global examination of vascular segments and identified luminal shape, wall thickness, and distribution and morphology of plaques. Reconstructions of aortic dissections illustrated the extent of the dissection and produced an anatomic picture of the false lumen. Three-dimensional imaging enhanced stent deployment by identifying the site for deployment, dimensions of the vessel lumen, and changes in morphology after stent insertion. There was good correlation in vessel dimensions measured by angiography, two-dimensional intravascular ultrasonography and longitudinal gray-scale reconstructions (r = 0.74 to 0.95; p = 0.34 to 0.001) but poor correlation with measurements from three-dimensional surface-rendered images (r = 0.13 to 0.48; p = 0.42 to 0.87). We conclude that three-dimensional intravascular ultrasound imaging is an innovative new method for identifying the type, extent, and spatial configuration of arterial disease, with promising diagnostic and therapeutic applications.
Subject(s)
Arteries/diagnostic imaging , Aortic Dissection/diagnostic imaging , Angiography , Animals , Aortic Aneurysm/diagnostic imaging , Arteriosclerosis/diagnostic imaging , Cadaver , Dogs , Femoral Artery/diagnostic imaging , Humans , Iliac Artery/diagnostic imaging , Image Processing, Computer-Assisted , Reference Values , Ultrasonography/methods , Vascular Diseases/diagnostic imagingABSTRACT
Intravascular ultrasonography is developing rapidly as a method for defining the transmural anatomy of vascular structures, with diagnostic and therapeutic applications. The ultrasound technology not only has unique diagnostic capabilities by defining the distribution and character of lesions, but also provides accurate control information regarding efficacy of angioplasty methods. An exciting recent development is the three-dimensional reconstruction of two-dimensional images which permits global examination of luminal and transmural vessel morphology. This technology may enable improved guidance of intraluminal devices to enhance lesion removal without damaging adjacent normal wall structure and appropriate device selection by differentiating specific plaque characteristics.
Subject(s)
Blood Vessels/diagnostic imaging , Animals , Humans , Methods , Ultrasonography , Vascular Diseases/diagnostic imagingABSTRACT
This report describes intravascular ultrasound imaging of a localized 81% stenosis in the left common iliac artery of a 52-year-old woman. The lesion was dilated using an 8 mm balloon and was imaged pre- and post-dilation using arteriography and a 5F, 30 Mhz intravascular ultrasound catheter. The same site was imaged again intraoperatively at two months following the initial procedure using an 8F, 20 Mhz intravascular ultrasound catheter when the patient had a femoropopliteal bypass for continuing ischemia. Intravascular ultrasound imaging allowed accurate, sequential, on-line calculation of the cross-sectional area and volume of the lesion both, acutely and following healing of the site. The morphology of the fractured arterial plaque was clearly defined, demonstrating distribution of calcification, and intraluminal flaps not apparent on arteriography. The case demonstrates the unique potential of intravascular ultrasound in assessing the immediate effect of interventions and evaluating the long-term healing.
Subject(s)
Angioplasty, Balloon , Arterial Occlusive Diseases/therapy , Iliac Artery/diagnostic imaging , Arterial Occlusive Diseases/diagnostic imaging , Female , Femoral Artery/surgery , Follow-Up Studies , Humans , Intraoperative Period , Middle Aged , Popliteal Artery/surgery , Radiography , Ultrasonography/methodsABSTRACT
Current angioplasty devices are limited by arterial wall dissection and perforation, and by early recurrence from inadequate debulking of lesions. This study evaluated intravascular ultrasound (IVUS) as guidance for concentric laser recanalization of arterial occlusions. Twelve, 2-4-cm-long canine iliac artery occlusions were treated at 2 weeks (organizing thrombus) to 12 weeks (firm fibrous lesions) using a Holmium:YAG laser (2,100 nm wavelength) in free running mode, FRM, (250 musec pulse, 5 Hz), n = 9; and Q-switched mode, QSM (200 ns pulse, 6 Hz), n = 3. A 200 microns (n = 2) or 600 microns (n = 10) optic fiber was centered in the artery coaxial to a 5Fr rotating A scan IVUS probe. The fiber was positioned in the center of the artery distal to the lesion and slowly advanced through the obstruction. In 8 occlusions the same fiber was used as a guidewire for passage of either a 1.6-mm-(n = 2) and/or 3.0-mm (n = 6) diameter multifiber catheter (19 x 100 and 19 x 200 microns fibers, respectively) using FRM energy to further debulk the lesion. In all cases, IVUS guidance enabled concentric initial recanalization of occlusions, although 3 vessel perforations resulted from fiber deviation off the center of the lumen at a distance of 2 to 4 cm from the IVUS imaging element. Both QSM and FRM modes ablated tissue, with FRM modes producing more tissue fragmentation and thermal effect. IVUS images accurately diagnosed the location of lesions compared to angioscopic views and pathologic analysis of the specimens.(ABSTRACT TRUNCATED AT 250 WORDS)
Subject(s)
Angioplasty, Laser/methods , Arterial Occlusive Diseases/surgery , Animals , Arterial Occlusive Diseases/diagnostic imaging , Arteriosclerosis/surgery , Dogs , Iliac Artery , Recurrence , UltrasonographyABSTRACT
Intravascular ultrasound (IVUS) is a new catheter-based system that produces two-dimensional (2D) images of vascular structures. Existing systems produce real-time, cross-sectional "slices" of vessels using 5.0 French (Fr) (30 MHz) and 8.0 Fr (20 MHz) IVUS catheters containing ultrasound transducers at the tip. Computerized, three-dimensional (3D) reconstruction of these 2D images using a personal computer- (PC) based image analysis system is described. A set (n = 90) of longitudinally aligned, consecutive images is sampled from a 5.0 cm vessel segment, and computerized processing creates rendered 3D images. By adjusting image density threshold and viewing angle, the morphology, location, and spatial distribution of arterial pathology can be seen. Refinements in computer hardware and software have reduced processing time and improved image resolution to the point where 3D IVUS imaging is a clinically applicable tool. Possible applications include diagnosis of complex arterial pathology, guidance of intraluminal instruments, and assessment of the effects of endovascular interventions.
Subject(s)
Blood Vessels/diagnostic imaging , Catheterization/instrumentation , Equipment Design , Humans , Image Processing, Computer-Assisted , Methods , Transducers , Ultrasonography , Videotape RecordingABSTRACT
Intraluminal ultrasound (ILUS) is a new catheter-based system which produces two-dimensional (2D), cross-sectional images of tubular structures. The principle of image acquisition using 5.0 Fr (30 MHz) and 8.0 Fr (20 MHz) ILUS catheters containing ultrasound transducers at the tip, is equally applicable to all tubular or hollow organs. This article illustrates the feasibility of intraluminal imaging of hollow organ structures, and describes computerized three-dimensional (3D) reconstruction of the 2D images, using a PC-based image analysis system. A set (n = 90) of longitudinally aligned, consecutive 2D images was sampled from various organs (canine bladder, urethra, jejunum, esophagus, and trachea) and computer processed to produce 3D images. By adjusting image density threshold and viewing angle, the lumen and wall morphology can be examined in any projection. Possible applications include diagnosis of lumen encroaching pathology, guidance of intraluminal instruments, and assessment of the effects of endoluminal interventions.
Subject(s)
Endoscopy/methods , Image Processing, Computer-Assisted , Ultrasonography/methods , Animals , Catheterization/instrumentation , Catheterization/methods , Dogs , Endoscopes , Equipment Design , Esophagus/diagnostic imaging , Jejunum/diagnostic imaging , Male , Prostate/diagnostic imaging , Rotation , Trachea/diagnostic imaging , Transducers , Ultrasonography/instrumentation , Urethra/diagnostic imaging , Urinary Bladder/diagnostic imaging , Videotape RecordingABSTRACT
This study assessed the utility of intraluminal ultrasound imaging during deployment of a self-expanding vascular stent and quantitated changes in arterial morphology produced by the stent. Cross-sectional images of arterial lumens (n = 50) were obtained before stenting, in-vitro (n = 35) from formalin-preserved human superficial femoral arteries and in-vivo (n = 15) from canine iliac arteries containing laser-induced eccentric stenoses. Comparison of ultrasound-derived vessel dimensions (minimum and maximum diameter and cross-sectional area) with histological morphometric analysis of corresponding vessel sites showed good correlation by linear regression analysis (r = 0.930-0.987, p = 0.001-0.005). Following stent placement, 23 intraluminal ultrasound images were obtained from the stented vessel sites (in-vitro n = 15, in-vivo n = 8) and were compared to prestented cross-sectional areas. In the in-vitro vessels there was a small increase (p = 0.023) in area, but there was no change in the in-vivo arteries (p = 0.6). To assess the effect of stenting on luminal shape (ellipticity), minimum/maximum diameter ratios were compared before and after stent deployment. There was an increase in this ratio in the in-vitro vessels (p = 0.001) but no change in the in-vivo arteries (p = 0.2). We conclude that intraluminal ultrasound produces clear and accurate images of the location, shape and degree of arterial pathology, ensuring good stent: vessel size matching and immediate quantitative assessment of the effects of arterial stent placement.
Subject(s)
Arterial Occlusive Diseases/diagnostic imaging , Stents , Animals , Arterial Occlusive Diseases/pathology , Arterial Occlusive Diseases/surgery , Disease Models, Animal , Dogs , Evaluation Studies as Topic , Female , Femoral Artery/diagnostic imaging , Humans , Iliac Artery/diagnostic imaging , In Vitro Techniques , Regression Analysis , UltrasonographyABSTRACT
A case of acute dissecting aortic aneurysm is described in which intravascular ultrasonography was used at the time of aortography to produce real-time, 360 degree cross-sectional images of the aorta. The transmural vessel morphology visualized by this new catheter-based technology allowed confirmation of the diagnosis and identification of distal extension to the aortic bifurcation. The case demonstrates the unique potential of this modality in diagnosis and possible therapy in vascular diseases.