ABSTRACT
BACKGROUND: Children with type 1 diabetes (T1D) are at much higher risk of developing celiac disease (CD) than the general population. The aim of the study was to assess the prevalence and differences in clinical presentation of CD in T1D in different regions of the world. METHODS: This study is based on the Better control in Pediatric and Adolescent diabeteS: Working to crEate cEnTers of Reference (SWEET) database. There were 57 375 patients included in the study, aged ≤18 years from 54 SWEET centers. Only centers with screening for celiac disease were included. Regression models adjusted for age, diabetes duration, and gender and a fixed effect in the models for region was used. Diabetes duration, age at diabetes onset, and sex were presented as unadjusted results. RESULTS: CD was present in 2652 subjects (4.5%), with different prevalence among regions: from 1.9% in Asia/Middle East to 6.9% in Australia/New Zealand. CD was observed more often among females. Comparing children with and without CD, characteristics for those with CD were younger age at diabetes onset (6.3 [3.3; 9.8] vs 8.1 [4.6; 11.3], P < 0.001) and had longer diabetes duration (6.4 [3.6; 9.8] vs 4.8 [2.1; 8.2], P < 0.001). Further, they had lower glycosylated hemoglobin (HbA1c) in Europe and North America/Canada; lower body mass index (BMI)-SD score (BMI-SDS) in southern Europe, North America, and Canada; In most regions daily insulin dose was lower, height-SDS was lower, and the percentage of insulin pump users was higher in children with T1D and CD. CONCLUSIONS: The prevalence and the anthropometric and metabolic consequences of CD in children with T1D differ around the world.
Subject(s)
Celiac Disease/epidemiology , Diabetes Mellitus, Type 1/epidemiology , Adolescent , Age of Onset , Celiac Disease/diagnosis , Child , Child, Preschool , Cross-Sectional Studies , Diabetes Mellitus, Type 1/diagnosis , Diabetes Mellitus, Type 1/drug therapy , Female , Health Status Disparities , Healthcare Disparities , Humans , Hypoglycemic Agents/administration & dosage , Insulin/administration & dosage , Insulin Infusion Systems , Male , Prevalence , Prognosis , Prospective Studies , Registries , Risk Assessment , Risk Factors , Sex Factors , Time FactorsABSTRACT
BACKGROUND: The Surgical Infection Society (SIS) guidelines for antibiotic (Ab) usage minimally changed the surgical practice. The authors believed that clinical evidence of the safety, advantage, and effectiveness of SIS guidelines may improve inappropriate usage of Ab. METHODS: A group of dedicated surgeons attempted to use Ab appropriately to SIS guidelines in their patients (group A). A comparison was made with a concurrent cohort of patients (group B), treated by surgeons who were nonsupporters of SIS guidelines. The trial was conducted in 378 children between March 1999 and May 2000. The outcome measures were morbidity and mortality rates, Ab treatment duration, timing of administration, unjustified spectrum, and switch of Ab. Analysis of variance and Chi2 test were used in statistics. P value less than.05 was considered significant (s). RESULTS: Group A included 124 patients and Group B, 254. There were no intergroup differences in age, sex, and clean/contaminated/dirty ratio of procedures. The mean duration of Ab treatment was 3.9 days in group A, versus 7.1 days in group B (s), with overall rate of appropriateness of 77% versus 36% (s) and no differences in mortality and morbidity rates. CONCLUSION: Perhaps these results may change Ab usage in pediatric surgery.
