ABSTRACT
BACKGROUND: To prove the efficacy of contrast-enhanced ultrasound (CEUS) in determining the extent of resection, more evidence about B-mode and CEUS as opposed to pathology is required. We compared maximum tumor width measured on B-mode/CEUS images with that determined pathologically. METHODS: In this retrospective multicenter study, 152 operable breast cancer patients who had undergone both B-mode and CEUS were analyzed. Maximum tumor width on B-mode and CEUS, and on the postoperative pathological examination (P), was measured by the participating investigators. In addition, maximum width was assessed in B-mode and CEUS image sets by independent reviewers blinded to all patient information. We analyzed differences in maximum width between CEUS, B-mode and P. RESULTS: The mean widths as measured by the participating investigators were 15 ± 7 mm (B-mode), 19 ± 8 mm (CEUS), and 17 ± 9 mm (P). The difference subtracted P from B-mode was - 3 ± 7 mm (p < 0.0001), and that from CEUS was 1 ± 6 mm (p = 0.0163). The mean widths as measured by the independent reviewers were 16 ± 7 mm (B-mode) and 18 ± 7 mm (CEUS). The difference subtracted P from B-mode was - 2 ± 8 mm (p = 0.0114), while that from CEUS was 1 ± 7 mm (p = 0.1921). CONCLUSIONS: Maximum lesion width measurement showed a tendency to increase in the order of B-mode, to P and CEUS. The difference in measurement between P and B-mode was significant, but there was no significant between CEUS and P. These results provide additional information of tendency patterns in measuring the maximum lesion width through enhancement on CEUS.
Subject(s)
Breast Neoplasms/diagnostic imaging , Breast Neoplasms/pathology , Contrast Media , Tumor Burden , Ultrasonography, Mammary/methods , Aged , Breast Neoplasms/epidemiology , Breast Neoplasms/surgery , Female , Humans , Japan/epidemiology , Mastectomy , Middle Aged , Retrospective StudiesABSTRACT
OBJECTIVE: Schizophrenia is a mental disorder characterized by severe cognitive impairment. Accumulating evidence suggests a role for oxidative stress in the pathophysiology of schizophrenia. Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity. In this study, we attempted to evaluate the effect of SFN on cognitive impairment in medicated patients with schizophrenia. METHODS: We recruited a total of 10 outpatients with schizophrenia, all of whom gave informed consent. Participants took 3 tablets of SFN, consisting of 30 mg of SFN-glucosinolate per day, for 8 weeks. Clinical symptoms using the Positive and Negative Syndrome Scale (PANSS) and cognitive function using the Japanese version of CogState battery were evaluated at the beginning of the study and at week 8. RESULTS: A total of 7 patients completed the trial. The mean score in the Accuracy component of the One Card Learning Task increased significantly after the trial. However, we detected no other significant changes in participants. CONCLUSION: This result suggests that SFN has the potential to improve cognitive function in patients with schizophrenia.
Subject(s)
Humans , Asian People , Brassica , Executive Function , Informed Consent , Learning , Mental Disorders , Outpatients , Oxidative Stress , Schizophrenia , TabletsABSTRACT
Neuroblastoma is a malignant tumor predominantly occurring in children and usually arising from the adrenal gland or sympathetic ganglia. We describe a neuroblastoma in a 1-month-old boy arising from his left orbital cavity. This tumor was refractory to chemotherapy or radiotherapy, requiring enucleation of the left eye for complete removal of the intraorbital tumor. Thereafter, he received high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation, and has been in complete remission for 3 years. Unlike neuroblastomas arising from the adrenal gland or sympathetic ganglia, primary orbital neuroblastoma may be refractory even in early infancy.
Subject(s)
Bone Marrow/pathology , Neoplasm Staging/methods , Neuroblastoma/diagnosis , Orbital Neoplasms/diagnosis , Biopsy , Diagnosis, Differential , Humans , Infant, Newborn , Male , Tomography, X-Ray ComputedABSTRACT
We report a case of chronic localized thoracoabdominal aortic dissection with an entry located just above the celiac artery which was successfully treated by patch aortoplasty. The patient was a 55-year-old man who complained of abdominal and back pain. CT scan and angiography showed a localized thoracoabdominal aortic dissection the entry of which was located just above the celiac artery. The patient underwent resection of the aneurysm and patch aortoplasty with the aid of a femoro-femoral bypass. The postoperative course was uneventful. Localized thoracoabdominal aortic dissection has been reported in only 5 cases, including our case, in the Japanese literature.
