1.
Mol Divers
; 7(2-4): 165-9, 2003.
Article
in English
| MEDLINE
| ID: mdl-14870846
ABSTRACT
A new efficient synthesis of optically active bicyclic 2-pyridiones has been developed using microwave irradiation. The synthesis is a two-step procedure via delta2-thiazolines, which only requires a 3 + 2 min reaction time compared to 2 days when using conventional heating. The optimized conditions proved to be suitable for the synthesis of a small library in excellent yields and with limited racemizations.