[Parameters of cellular adaptation in newborn infants in health and in perinatal injuries of the CNS]. / Pokazateli kletochnoi adaptatsii u novorozhdennykh v norme i pri perinatal'nykh povrezhdeniiakh TsNS.

A study was made of the level of compensatory and adaptive reactions in red blood cells (intensity of membranous metabolism, lipid peroxidation, malonic dialdehyde (MDA) metabolism, changes in the correlation of lipid fractions) in the newborn in health and in perinatal CNS injuries within the first days of life. Changes in the indicated parameters were examined after preincubation of red blood cells under physiologic conditions and by means of MDA addition to the incubation medium. It is concluded that the newborn with perinatal CNS injuries are marked by metabolic inertness and reduced cellular adaptation in red blood cells preincubated under physiologic conditions as well as by pronounced disadaptation under the conditions of excess MDA.

[Degradation of malonic dialdehyde in erythrocytes and its age-, seasonal- and circadian-dependent changes]. / Degradatsiia malonovogo dial'degida v éritrotsitakh i ee vozrastnye, sezonnye i sutochnye izmeneniia.

A rate of malonic dialdehyde (MDA) degradation was studied in erythrocytes of newborns within the first and 4-5th days of life, of 5-6 and 8-14 years old children and of 18-28 and 35-49 years old adult persons by means of introduction of exogenous MDA into the mixture containing erythrocytes and estimation of the aldehyde elimination during incubation. Intensity of MDA degradation correlated with its content in erythrocytes. Age-, season- and circadian-dependent alterations were detected in the rate of MDA degradation as well as in the ratio of this value to the total content of MDA (index D/M). The lowest rate of MDA degradation and the index D/M value were observed in the persons of the older age group (35-49 years old). Either in 8-14 years old children or in adult persons the index D/M exhibited higher values in summer time as compared with other seasons. Distinct circadian alterations of the patterns studied were found in 18-28 years old persons but these patterns were dissimilarly directed during a day in newborns.