ABSTRACT
Therapeutic effect of sodium diclofenac during fever reaction is associated not only with specific modulation of thermoregulation, but also with the increase in the count of lymphocytes transported with the lymph into systemic circulation, stimulation of lymph microcirculation, and improvement of metabolism in the interstitial space. This preparation inhibited kininogenesis and stimulated degradation of kinins. Sodium diclofenac serves as a universal inhibitor of the kallikrein-kinin system.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Diclofenac/pharmacology , Fever/metabolism , Lymph/chemistry , Microcirculation/drug effects , Animals , Female , Fever/chemically induced , Kallikreins/metabolism , Kinins/metabolism , Male , RatsABSTRACT
Orthophen improved lymph flow during fever reaction via stimulation of contractile activity of the wall and valves in mesenteric lymphatic vessels of rat small intestine. These changes constitute the pathogenetic mechanism for the effect of orthophen during fever.
