The dataset on the draft whole-genome sequences of two Pseudomonas aeruginosa strains isolated from urine samples of patients with urinary tract diseases.

Pseudomonas aeruginosa is a widespread multidrug-resistant opportunistic human pathogen with an extremely high mortality rate that leads to urinary tract infection morbidities in particular. Variability and dynamics in genome features and ecological flexibility help these bacteria adapt to many environments and hosts and underlie their broad antibiotic resistance. Overall, studies aimed at obtaining a deeper understanding of the genome organization of UTI-associated P. aeruginosa strains are of high importance for sustainable health care worldwide. Herein, we report the draft assembly of entire genomes of two P. aeruginosa strains, PA18 and PA23, isolated from voided urine of patients with urinary tract diseases (hydronephrosis and urolithiasis, respectively) and determine the most important genetic features for pathogenesis and virulence. Whole-genome sequencing and annotation of genomes revealed high similarity between the two UTI strains along with differences in comparison with other uropathogenic P. aeruginosa and reference strains. The 6 981 635 bp and 6 948 153 bp draft genome sequences with GC contents of 65.9% and 65.8%, respectively, provide new insights into the virulence genetic factors and genes associated with antimicrobial resistance. The whole genome data of PA18 and PA23 have been deposited in the NCBI GenBank database (accession numbers JAQRBF000000000.1 and JAQRBG000000000.1, respectively).

[Relationship between the frequency and amplitude of myocardial contractions in rats adapted to heat]. / Zavisimost' mezhdu chastotoi i amplitudoi sokrashchenii serdechnoi myshtsy u adaptirovannykh k teplu krys.

Papillary muscles from the left ventricle of rats contracted under the effect of electrostimulation with the frequency of 0.2 c. p. s. in Krebs' solution at 28 degrees C. A study was made of the contraction amplitude with the increased stimulation frequency. Following preliminary heat adaptation (3 hours a day at 35 degrees C for one month) the contraction amplitude of the myocardium of the adapted animals with a high frequency was greater than the control level. This difference persisted at 36 degrees C and disappeared at 25 degrees C. Apparently adaptation leaves a definite structural trace in the cells of the cardiac muscle.