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16.
Science ; 166(3911): 1433-5, 1969 Dec 12.
Article in English | MEDLINE | ID: mdl-5307630

ABSTRACT

p-Chlorophenylalanine depletes brain serotonin and induces longlasting sexual excitation in male rats. The effect of p-chlorophenylalanine is potentiated by pargyline. Administration of 5-hydroxytryptophan to rats treated with p-chlorophenylalanine plus pargyline blocks the sexual excitation. p-Chlorophenylalanine also elicits sexual excitation in pinealectomized rats; this effect is not mediated by the lack of indole hormones in the pineal but may be the consequence of depletion of 5-hydroxytryptophan in the brain and the resulting imbalance between 5-hydroxytryptophan and catecholamine activity in the central nervous system.


Subject(s)
Compulsive Behavior/drug effects , Phenylalanine/pharmacology , Pineal Gland/surgery , Sexual Behavior, Animal/drug effects , 5-Hydroxytryptophan/pharmacology , Animals , Brain Chemistry , Chloramines/pharmacology , Humans , Male , Pargyline/pharmacology , Rats , Serotonin Antagonists
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