ABSTRACT
OBJECTIVE: This study was performed to evaluate the possible influence of magnesium sulphate which has sedative and analgesic properties on sevoflurane-induced emergence agitation in paediatric patients undergoing adenoidectomy with or without tonsillectomy. METHODS: One hundred and ten paediatric patients aged between 3 and 16 years were randomly allocated to the study. Propofol 2-2.5 mg kg(-1), vecuronium 0.1 mg kg(-1) and fentanyl 1 µg kg(-1) were used for induction of anesthesia and sevoflurane at 1 MAC with nitrous oxide in oxygen (35%) mixture was administered as maintenance. Magnesium sulfate 30 mg kg(-1) in saline (20 mL) in the Group M, or equal volume of saline for controls (Group C) was started 10 min before and infused until the end of the operation. Recovery characteristics included time to extubation, eyes open, emergence and interaction. Patients were evaluated using Modified Aldrete Score (MAS), Pain/Discomfort Scale and Agitation Score. Side effects were determined during emergence and in the recovery. RESULTS: Time to open eyes was significantly higher in the magnesium treatment group (GroupC: 7.7±3.5, Group M: 12.7±17.5 min, p=0.001). Agitation score was significantly lower in Group M at the 60th min (Group C: 1.3±0.7, Group M: 1.0±0.3, p=0.005). Agitation or pain/discomfort scores in the resting observation periods were the same. The initial MAS value was lower in Group M (Group C: 5.0±1.9, Group M: 4.0±1.7, p=0.003). There was no significant difference between groups regarding side effects. CONCLUSION: Magnesium sulphate infusion has no influence on sevoflurane-induced discomfort or emergence agitation.
Subject(s)
Adenoidectomy , Anesthesia Recovery Period , Anesthesia, General/adverse effects , Anesthetics, Inhalation/adverse effects , Hypnotics and Sedatives/administration & dosage , Magnesium Sulfate/administration & dosage , Methyl Ethers/adverse effects , Otorhinolaryngologic Surgical Procedures , Psychomotor Agitation/prevention & control , Tonsillectomy , Adolescent , Anesthetics, Combined , Anesthetics, Intravenous , Child , Child, Preschool , Fentanyl , Humans , Infusions, Intravenous , Neuromuscular Nondepolarizing Agents , Nitrous Oxide , Propofol , Psychomotor Agitation/etiology , Sevoflurane , Vecuronium BromideABSTRACT
OBJECTIVE: To investigate the effects of septoplasty on pulmonary function tests (PFTs) and bronchial hyperresponsiveness (BHR) in patients who had no previous pulmonary diseases. DESIGN: Prospective, controlled clinical trial. PATIENTS: Fourteen patients with nasal septal deviation (NSD) and 20 controls were enrolled in the study. MAIN OUTCOME MEASURES: All patients were evaluated with anterior rhinoscopy, nasal endoscopy, acoustic rhinometry (AR), visual analogue scale (VAS), PFTs, and bronchoprovocation test (BPT) on the day before surgery and 8 to 12 weeks after surgery. RESULTS: The postoperative values of forced expiratory volume in 1 second, forced vital capacity, and peak expiratory flow percentages were higher than preoperative ones, and these results were statistically significant (p = .007, p = .04, and p = .007, respectively). Nine patients had preoperative BHR, and three of them had negative BPT postoperatively. When compared with the preoperative values, there was a borderline decrease in the rate of BHR in six patients. There were significant improvements in the symptoms of left and right nasal congestion, headache, postnasal drip, and olfactory function after surgery. We found important improvement in the values of AR at right minimal cross-sectional area 1 (p = .02), left distance 1 (p = .04), and left distance 2 (p = .04) postoperatively. CONCLUSION: An improvement in both nasal symptoms and PFT values was seen after surgical treatment for NSD. We concluded that septoplasty may be considered as having favourable effects on BHR.
