[Formation of antibiotic JI-20B by a culture of Streptomyces flavovirens]. / Obrazovanie antibiotika J120-B kul'turoi Streptomyces flavovirens.

An actinomycetous culture having an antibiotic action on gram-positive and gram-negative bacteria was isolated from a soil sample collected in the region of the Balaton Lake. As a result of the taxonomic study the culture was classified as Str. flavovirens. Waksman, Henrici (1948). Examination of antimicrobial properties of the antibiotic and chromatographic and mass-spectroscopic studies allowed one to classify it as an aminoglycoside belonging to the gentamicin group. The antibiotic was designated as J120-B. Until recently such antibiotics were known to be produced only by Micromonospora.

[New anthracycline antibiotics taurimycins A and B produced by a Str. tauricus No. 7036-1 culture]. / Novye antratsiklinovye antibiotiki tavrimitsiny A i B, produtsiruemye kul'turoi Str. tauricus No. 7036-1.

Taurimycins A and B are new anthracycline antibiotics belonging to the group of glycosides. They were isolated from the mycelium of culture 7036-1 classified with Str. tauricus. The empiral formula of taurimycin A is C14H51O16N,M+813. The empirical formula of taurimycin B is C41H49O16N,M+811. The absorption maxima in the UV spectra of the antibiotics (in alcohol solutions) were observed at 235, 257, 292, 466, 482, 494, 515 and 527 nm. The IR spectra showed absorption bands at 3450, 2945, 2870, 1740 and 1610 cm-1. Hydrolysis of the antibiotics with hydrochloric acid resulted in formation of an aglycone identified as epsilon-pyrromycinone.

[Identification of the antibiotic formed by a Str. canulus 106/78 culture with antibiotic CC-1065]. / Identifikatsiia antibiotika, obrazuemogo kul'turoi Str. canulus 106/78, s antibiotikom CC-1065.

An antibiotic with a melting point of at least 340 degrees C, [alpha]D + 100 degrees (c 1 per cent in dimethylformamide) was isolated from the mycelium of Str. canulus 106/78. Calculated (%): C 60.63, H 4.69, N 13.6. The UV spectrum of the antibiotic (in methanol solution) showed the terminal absorption, shoulder at 265 nm and maximum at 375 nm. In dimethylformamide solution the UV absorption maximum was observed at 370 nm with E1 1% cm 845. The IR, FMR and 13C-NMR spectra of antibiotic 106 are analogous to the respective spectra of antibiotic CC-1065 which is indicative of their identity.

[New antibiotic, cinropeptin, from a culture of Act. cineraceus]. / Novyi antibiotik tsinropeptin iz kul'tury Act. cineraceus.

Cinropeptin, a new antibacterial antibiotic, was isolated from the mycelium of a culture classified as belonging to Act. cineraceus. Its empirical formula is C50H63N11O12S6, [alpha]D--169.4 degrees (C 0.36, CHCl3). The UV absorption maxima of the antibiotic in an alcoholic solution were observed at 218, 232, 304 and 365 nm. The IR absorption bands were recorded at 3370, 1660, 1600, 1530, 1140 and 1100 cm-1. Cystin, glycine and methylamine were detected in the acid hydrolysate of cinropeptin. Study on the products of the antibiotic partial oxidation with performic acid and comparison of the sulfur percentage and molecular weight showed that the molecule of cinropeptin contained 3 residues of cystin.