Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Leuk Lymphoma ; 54(3): 520-7, 2013 Mar.
Article in English | MEDLINE | ID: mdl-22830614

ABSTRACT

Approximately 50% of patients with adult T-cell leukemia/lymphoma (ATLL) have skin involvement, and the smoldering, skin lesion-bearing cases are often treated with various skin-directed therapies, such as phototherapy and radiation therapy. Daily oral administration of etoposide plus prednisolone (EP) is also used for smoldering-type ATLL. However, it remains unclear whether these therapies improve patients' survival. We retrospectively analyzed the prognosis of patients with smoldering, skin lesion-bearing ATLL (n = 62), who were treated, as first therapy, with one skin-directed therapy (n = 29), oral EP alone (n = 14) or a combination of skin-directed therapy and oral EP (n = 19). Multivariate analysis revealed that the hazard ratios (HRs) for the overall survival (OS) and progression-free survival (PFS) with the combination therapy were significantly lower than those with the skin-directed therapy (HR 0.1, p = 0.001; HR 0.2, p = 0.002, respectively). These results suggest that the combination of skin-directed therapy and oral EP improves the clinical outcome of patients with smoldering, skin lesion-bearing ATLL.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Leukemia-Lymphoma, Adult T-Cell/therapy , Skin/radiation effects , Ultraviolet Therapy/methods , Administration, Oral , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Combined Modality Therapy , Drug Administration Schedule , Etoposide/administration & dosage , Etoposide/adverse effects , Fatigue/etiology , Female , Humans , Kaplan-Meier Estimate , Leukemia-Lymphoma, Adult T-Cell/pathology , Leukopenia/etiology , Male , Middle Aged , Multivariate Analysis , Outcome Assessment, Health Care/statistics & numerical data , Prednisolone/administration & dosage , Prednisolone/adverse effects , Proportional Hazards Models , Retrospective Studies , Skin/pathology , Ultraviolet Therapy/adverse effects , Vomiting/etiology
2.
Blood ; 117(15): 3961-7, 2011 Apr 14.
Article in English | MEDLINE | ID: mdl-21325600

ABSTRACT

Cutaneous involvement is seen in ~ 50% of adult T-cell leukemia/lymphoma (ATLL) patients. We investigated the association between skin eruption type and prognosis in 119 ATLL patients. ATLL eruptions were categorized into patch (6.7%), plaque (26.9%), multipapular (19.3%), nodulotumoral (38.7%), erythrodermic (4.2%), and purpuric (4.2%) types. When the T stage of the tumor-node-metastasis-blood (TNMB) classification of mycosis fungoides/Sézary syndrome was applied to ATLL staging, 16.0% were T1, 17.7% T2, 38.7% T3, and 4.2% T4, and the remaining 23.5% were of the multipapular and purpuric types. For the patch type, the mean survival time (median survival time could not be estimated) was 188.4 months. The median survival times (in months) for the remaining types were as follows: plaque, 114.9; multipapular, 17.3; nodulotumoral, 17.3; erythrodermic, 3.0; and purpuric, 4.4. Kaplan-Meier curves of overall survival showed that the erythrodermic type had the poorest prognosis, followed by the nodulotumoral and multipapular types. The patch and plaque types were associated with better survival rates. Multivariate analysis demonstrated that the hazard ratios of the erythrodermic and nodulotumoral types were significantly higher than that of the patch type, and that the eruption type is an independent prognostic factor for ATLL. The overall survival was worse as the T stage became more advanced: the multipapular type and T2 were comparable, and the purpuric type had a significantly poorer prognosis than T1.


Subject(s)
Leukemia-Lymphoma, Adult T-Cell/mortality , Leukemia-Lymphoma, Adult T-Cell/pathology , Skin Neoplasms/mortality , Skin Neoplasms/pathology , Skin/pathology , Adult , Aged , Aged, 80 and over , Female , Humans , Kaplan-Meier Estimate , Leukemia-Lymphoma, Adult T-Cell/classification , Male , Middle Aged , Multivariate Analysis , Predictive Value of Tests , Prognosis , Skin Neoplasms/classification , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL
...