Subject(s)
Adrenal Cortex Hormones/administration & dosage , Purpura, Thrombocytopenic, Idiopathic/therapy , Risk Assessment , Splenectomy , Adrenal Cortex Hormones/adverse effects , Animals , Arteriosclerosis/etiology , Cardiovascular Diseases/chemically induced , Diabetes Mellitus/chemically induced , Humans , Hypertension, Pulmonary/etiology , Mice , Osteoporosis/chemically induced , Physician-Patient Relations , Prednisolone/administration & dosage , Prednisolone/adverse effects , Rats , Splenectomy/adverse effects , Thromboembolism/etiologyABSTRACT
Accurate assessment of residual disease is important for the prediction of outcome in patients with acute leukaemia in complete remission (CR). To investigate whether abnormalities on magnetic resonance (MR) images of femoral marrow in adult patients with acute myeloid leukaemia (AML) in CR can predict outcome, 28 newly diagnosed patients with AML underwent MR imaging when bone marrow aspiration or biopsy was performed to verify the state of CR after induction therapy. MR abnormalities on short TI (inversion time) inversion recovery (STIR) techniques persisted in all four patients who did not achieve CR. In 13 CR patients abnormalities on STIR images resolved, to result in normal appearance at the time CR was achieved. All 13 patients remained in CR for 3-104 months (median, 73 months). In the other 11 CR patients, STIR abnormalities persisted at the time CR was achieved. Seven of them relapsed between 1 and 28 months (median, 3 months) after MR evaluation. Disease-free survival of patients with persistent abnormal STIR images was significantly shorter than that of patients with normal STIR images (P < 0.01). MR imaging of femoral marrow may predict outcome in adult patients with AML in CR.
